US4289751A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof
Assignee: Merck and Co Inc
•
Filing: 1980-03-17
•
Granted: 1981-09-15
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Expires: 2000-03-17
Abstract
Abstract Improved delivery and absorption of erythromycin in warm-blooded animals is achieved by administering thereto a non-toxic pharmaceutical effervescent enteric-coated tablet comprising: (a) an antibiotic effective amount of a non-toxic pharmaceutically acceptable soluble form of erythromycin; (b) a non-toxic pharmaceutically acceptable inert diluent; and (c) a non-toxic pharmaceutically acceptable effervescent couple acid and base; and (d) a non-toxic pharmaceutically acceptable enteric coating maintained over the tableted mixture of (a), (b), and (c) above. The subject composition is extremely useful in the treatment of bacterial infections in warm-blooded animals, particularly in the mitigation and treatment of upper and lower respiratory tract, skin and soft tissue infections of mild to moderate severity.
Inventors
- 👤 John J. Windheuser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/0002; A61K9/0007; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
80 words
A pharmaceutically acceptable effervescent enteric-coated tablet for orally delivering therapeutic levels of erythromycin to a warm-blooded animal, which comprises a tableted admixture of: (a) an antibiotic effective amount of a non-toxic pharmaceutically acceptable salt of erythromycin which is readily soluble in the intestines; (b) a non-toxic pharmaceutically acceptable inert diluent; and (c) a non-toxic pharmaceutically acceptable effervescent couple acid and base; and (d) a non-toxic pharmaceutically acceptable enteric coating maintained over the tableted admixture of (a), (b), and (c) above.
Claim 2
Dependent Claim
80 words
A pharmaceutically acceptable effervescent enteric-coated tablet for orally delivering therapeutic levels of erythromycin to a warm-blooded animal, which comprises a tableted admixture of: (a) an antibiotic effective amount of a non-toxic pharmaceutically acceptable salt of erythromycin which is readily soluble in the intestines; (b) a non-toxic pharmaceutically acceptable inert diluent; and (c) a non-toxic pharmaceutically acceptable effervescent couple acid and base; and (d) a non-toxic pharmaceutically acceptable enteric coating maintained over the tableted admixture of (a), (b), and (c) above.
Claim 3
Dependent Claim
14 words
The tablet of claim 1, wherein said soluble salt of erythromycin is erythromycin lactobionate.
Claim 4
Dependent Claim
14 words
The tablet of claim 1, wherein said soluble salt of erythromycin is erythromycin glucoheptonate.
Claim 5
Dependent Claim
10 words
The tablet of claim 1, wherein said diluent is talc.
Claim 6
Dependent Claim
24 words
The tablet of claim 1, wherein said acid is a member selected from the group consisting of tartaric acid, citric acid, and phthalic acid.
Claim 7
Dependent Claim
11 words
The tablet of claim 1, wherein said base is sodium bicarbonate.
Claim 8
Dependent Claim
24 words
The tablet of claim 1, wherein said enteric coating is a member selected from the group consisting of cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate.
Claim 9
Dependent Claim
23 words
The tablet of claim 7, wherein said hydroxypropylmethylcellulose phthalate is a member selected from the group consisting of hydroxypropylmethylcellulose phthalate-50 and hydroxypropylmethylcellulose phthalate-45.
Claim 10
Dependent Claim
14 words
The tablet of claim 1, further comprising microcrystalline cellulose as a dry binding agent.
Claim 11
Dependent Claim
23 words
A method for inducing therapeutic levels of erythromycin in a warm-blooded animal which comprises administering thereto a tablet as claimed in claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-14 | 1985-03-16 | 1985-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-14 | 1989-03-16 | 1989-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-14 | 1993-03-16 | 1993-09-15 | $7700.00 | Window Closed / Lapsed |