N-Arylsulfonylpyrroles, their preparation, and therapeutic agents containing these compounds

Abstract

Abstract Compounds of the formula 1 ##STR1## where R 1 is a saturated, unsubstituted or substituted aliphatic radical of 1 to 8 carbon atoms, an unsaturated alkyl radical of 2 to 8 carbon atoms, a cycloalkyl radical of 3 to 7 carbon atoms in the ring or an alkyl radical of 1 to 4 carbon atoms which is substituted by phenyl or by a 5- or 6-membered aromatic heterocyclic ring containing an N, O or S atom, the phenyl ring or the heterocyclic ring itself being unsubstituted, monosubstituted or polysubstituted, and R 2 is hydrogen or R 1 and R 2 together with the nitrogen are a 4-membered to 6-membered cycloaliphatic saturated heterocyclic ring, R 3 is hydrogen or alkyl of 1 to 5 carbon atoms, R 4 and R 5 are identical or different and each is hydrogen or alkyl of 1 to 5 carbon atoms, X is oxygen, sulfur or >SO- or >NH- and Ar is unsubstituted, monosubstituted, disubstituted or trisubstituted phenyl, and their therapeutically useful ammonium salts, alkali metal salts or acid addition salts, which compounds and salts thereof exhibit valuable pharmacological properties, their preparation, therapeutic agents containing these products, and their use as drugs.

Inventors

• 👤 Jens-Uwe Bliesener
• 👤 Karl-Heinz Geiss
• 👤 Dieter Lenke
• 👤 Claus D. Mueller

Bibliographic Details