US4288368A
Expired / Lapsed
US
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Dithioacylproline derivatives
Assignee: ER Squibb and Sons LLC
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Filing: 1979-07-30
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Granted: 1981-09-08
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Expires: 1999-07-30
Abstract
Abstract Compounds having the formula ##STR1## wherein: R 1 is hydrogen, alkyl, aryl or arylalkyl; R 2 is hydrogen and R 3 is hydrogen, hydroxy, alkoxy or halogen, or together R 2 and R 3 can be ═O or --X--(CH 2 ) t --X-- wherein X is oxygen or sulfur and t is 2 or 3; R 4 is hydrogen or alkyl; R 5 is hydrogen, alkyl or trifluoromethyl; R 6 is alkyl of 1 to 20 carbon atoms, aryl, arylalkyl or a 5- or 6-membered heterocyclic group having 1 or 2 nitrogen, sulfur or oxygen atoms in the ring; R 7 is aryl; m is 0, 1 or 2; and n is 1 or 2 have useful hypotensive activity.
Inventors
- 👤 Rudiger D. Haugwitz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 20:28
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/06; A; A61; A61K; A61K31/00; A61K31/33; A61K31/38; A61K31/395; A61K31/40; A61K31/41; A61K31/415; A61P; A61P9/00; A61P9/12; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
1 words
(S)-1-[2-Methyl-1-oxo-3-[(2-thienylthioxomethyl)-thio]propyl]-L-proline.
Claim 2
Dependent Claim
1 words
(S)-1-[2-Methyl-1-oxo-3-[(2-thienylthioxomethyl)-thio]propyl]-L-proline.
Claim 3
Dependent Claim
1 words
(S)-1-[2-Methyl-1-oxo-3-[(1-thioxooctadecyl)thio]-propyl]-L-proline.
Claim 4
Dependent Claim
1 words
(S)-1-[2-Methyl-1-oxo-3-[(1-thioxooctadecyl)thio]-propyl]-L-proline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-07 | 1985-03-09 | 1985-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-07 | 1989-03-09 | 1989-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-07 | 1993-03-09 | 1993-09-08 | $7700.00 | Window Closed / Lapsed |