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US4282237A
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Method with substituted 1-benzyl-1H-indazole-3-carboxylic acids for interrupting pregnancy in mammals
Assignee: Angelini Acraf SpA
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Filing: 1978-08-08
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Granted: 1981-08-04
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Expires: 1998-08-08
Abstract
Abstract This invention relates to the use of substituted 1-benzyl-1H-indazole-3-carboxylic acids to interrupt pregnancy. These compounds are described in the U.S. Pat. No. 3,895,026 assigned to the same assignee of the present patent application.
Inventors
- 👤 Bruno Silvestrini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:58
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; Y; Y10; Y10S; Y10S424/00; Y10S424/12; Y10S424/14
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
134 words
A process for interrupting pregnancy and causing resorption of the fetus in a pregnant female which comprises administering to said female an effective amount therefor of at least one compound belonging to the class of substituted 1-benzyl-1H-indazole-3-carboxylic acids, amides and esters having the Formula (I) ##STR2## wherein R is H, CH 3 , OCH 3 , halogen; R 1 is H, CH 3 , or halogen; R 2 is halogen, CH 3 , OCH 3 , CF 3 , CONH 2 , SO 2 CH 3 ; R 3 is H, halogen; R 4 is OH, NH 2 , OR 5 ; R 5 being an easily hydrolyzable group --CH 2 CH 2 OH, --CH 2 CHOH CH 2 OH or --CH(CH 2 OH) 2 , and the pharmaceutically acceptable salts of these compounds.
Claim 2
Dependent Claim
134 words
A process for interrupting pregnancy and causing resorption of the fetus in a pregnant female which comprises administering to said female an effective amount therefor of at least one compound belonging to the class of substituted 1-benzyl-1H-indazole-3-carboxylic acids, amides and esters having the Formula (I) ##STR2## wherein R is H, CH 3 , OCH 3 , halogen; R 1 is H, CH 3 , or halogen; R 2 is halogen, CH 3 , OCH 3 , CF 3 , CONH 2 , SO 2 CH 3 ; R 3 is H, halogen; R 4 is OH, NH 2 , OR 5 ; R 5 being an easily hydrolyzable group --CH 2 CH 2 OH, --CH 2 CHOH CH 2 OH or --CH(CH 2 OH) 2 , and the pharmaceutically acceptable salts of these compounds.
Claim 3
Dependent Claim
18 words
A process according to claim 1, wherein said effective amount comprises between about 2 to 20 mg./kg. p.o.
Claim 4
Dependent Claim
15 words
A process according to claim 1, wherein the compound of formula I is 1-(4-chlorobenzyl)-1H-indazole-3-carboxylic acid.
Claim 5
Dependent Claim
15 words
A process according to claim 1, wherein the compound of formula I is 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid.
References Cited (Backward Citations)
US3895026A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-03 | 1985-02-02 | 1985-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-03 | 1989-02-02 | 1989-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-03 | 1993-02-02 | 1993-08-04 | $7700.00 | Window Closed / Lapsed |