Patent US4282215A successfully refreshed from Google Patents.
US4282215A
Expired / Lapsed
US
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Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
Assignee: Bristol Myers Squibb Pharma Co
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Filing: 1980-07-28
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Granted: 1981-08-04
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Expires: 2000-07-28
Abstract
Abstract A composition consisting essentially of nalbuphine and acetylsalicylic acid, derivative or salt thereof, gives unexpectedly enhanced analgetic activity.
Inventors
- 👤 John R. Dudzinski
- 👤 William K. Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 22:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
48 words
A pharmaceutical composition consisting essentially of (a) nalbuphine or a pharmaceutically suitable acid addition salt thereof and (b) acetylsalicylic acid, sodium acetylsalicylate, calcium acetylsalicylate, salicylic acid, or sodium salicylate or any combination thereof in a weight ratio of (a) to (b) of from about 1:1.76 to about 1:61.7.
Claim 2
Dependent Claim
48 words
A pharmaceutical composition consisting essentially of (a) nalbuphine or a pharmaceutically suitable acid addition salt thereof and (b) acetylsalicylic acid, sodium acetylsalicylate, calcium acetylsalicylate, salicylic acid, or sodium salicylate or any combination thereof in a weight ratio of (a) to (b) of from about 1:1.76 to about 1:61.7.
Claim 3
Dependent Claim
16 words
A composition of claim 1 wherein component (b) is acetylsalicylic acid, sodium acetylsalicylate or calcium acetylsalicylate.
Claim 4
Dependent Claim
11 words
A composition of claim 2 wherein component (b) is acetylsalicylic acid.
Claim 5
Dependent Claim
11 words
A composition of claim 2 wherein component (b) is sodium acetylsalicylate.
Claim 6
Dependent Claim
11 words
A composition of claim 2 wherein component (b) is calcium acetylsalicylate.
Claim 7
Dependent Claim
16 words
A composition of claim 2 wherein the weight ratio is from about 1:3 to about 1:50.
Claim 8
Dependent Claim
16 words
A composition of claim 2 wherein the weight ratio is from about 1:12 to about 1:45.
Claim 9
Dependent Claim
14 words
A composition of claim 2 wherein the nalbuphine is present as the hydrochloride salt.
Claim 10
Dependent Claim
13 words
A composition of claim 1 which contains in addition a suitable pharmaceutical carrier.
Claim 11
Dependent Claim
13 words
A composition of claim 2 which contains in addition a suitable pharmaceutical carrier.
Claim 12
Dependent Claim
13 words
A composition of claim 3 which contains in addition a suitable pharmaceutical carrier.
Claim 13
Dependent Claim
13 words
A composition of claim 4 which contains in addition a suitable pharmaceutical carrier.
Claim 14
Dependent Claim
13 words
A composition of claim 5 which contains in addition a suitable pharmaceutical carrier.
Claim 15
Dependent Claim
13 words
A composition of claim 6 which contains in addition a suitable pharmaceutical carrier.
Claim 16
Dependent Claim
13 words
A composition of claim 7 which contains in addition a suitable pharmaceutical carrier.
Claim 17
Dependent Claim
13 words
A composition of claim 8 which contains in addition a suitable pharmaceutical carrier.
Claim 18
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 1.
Claim 19
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 2.
Claim 20
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 3.
Claim 21
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 4.
Claim 22
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 5.
Claim 23
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 6.
Claim 24
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 7.
Claim 25
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 8.
References Cited (Backward Citations)
US3393197A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-03 | 1985-02-02 | 1985-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-03 | 1989-02-02 | 1989-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-03 | 1993-02-02 | 1993-08-04 | $7700.00 | Window Closed / Lapsed |