Phenylacetate anti-inflammatory composition

Claim 1

An anti-inflammatory composition, comprising: (1) from about 10 mg to about 500 mg of a phenylacetic acid-based compound selected from the group consisting of fenoprofen, ketoprofen, MK-830 having the formula ##STR5## and pharmaceutically-acceptable salts and esters thereof; and (2) from about 50 mg. to about 250 mg. of an organophosphonate compound selected from the group consisting of geminal organophosphonates of the formula ##STR6## or pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to about 10; R 3 is selected from the group consisting of H, --CH 2 OH, C 1 -C 20 alkyl or cycloalkyl, C 2 -C 20 alkenyl, aryl, phenylethyl, benzyl, halogen, amino, substituted amino, --CH 2 COOH, --CH 2 PO 3 H 2 , --CH(PO 3 H 2 ) (OH) or --CH 2 CH(PO 3 H 2 ) 2 ; and R 4 is selected from the group consisting of H, lower alkyl, amino, benzyl, halogen, --OH, --CH 2 COOH, --CH 2 PO 3 H 2 or --CH 2 CH 2 PO 3 H 2 .

Claim 11

A method for treating or preventing pain and inflammation in animal tissues, comprising administering to an animal in need of such treatment: (1) from about 50 mg to about 6000 mg per day of a phenylacetic acid-based compound selected from the group consisting of fenoprofen, ketoprofen, MK-830 having the formula ##STR7## and pharmaceutically-acceptable salts and esters thereof; and (2) from about 200 mg to about 2000 mg per day of an organophosphonate compound selected from the group consisting of geminal organophosphonates of the formula ##STR8## or pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to about 10; R 3 is selected from the group consisting of H, --CH 2 OH, C 1 -C 20 alkyl or cycloalkyl, C 2 -C 20 alkenyl, aryl, phenylethyl, benzyl, halogen, amino, substituted amino, --CH 2 COOH, --CH 2 PO 3 H 2 , --CH(PO 3 H 2 ) (OH) or --CH 2 CH(PO 3 H 2 ) 2 ; and R 4 is selected from the group consisting of H, lower alkyl, amino, benzyl, halogen, --OH, --CH 2 COOH, --CH 2 PO 3 H 2 or --CH 2 CH 2 PO 3 H 2 .

Claim 12

A method for treating or preventing pain and inflammation in animal tissues, comprising administering to an animal in need of such treatment: (1) from about 50 mg to about 6000 mg per day of a phenylacetic acid-based compound selected from the group consisting of fenoprofen, ketoprofen, MK-830 having the formula ##STR7## and pharmaceutically-acceptable salts and esters thereof; and (2) from about 200 mg to about 2000 mg per day of an organophosphonate compound selected from the group consisting of geminal organophosphonates of the formula ##STR8## or pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to about 10; R 3 is selected from the group consisting of H, --CH 2 OH, C 1 -C 20 alkyl or cycloalkyl, C 2 -C 20 alkenyl, aryl, phenylethyl, benzyl, halogen, amino, substituted amino, --CH 2 COOH, --CH 2 PO 3 H 2 , --CH(PO 3 H 2 ) (OH) or --CH 2 CH(PO 3 H 2 ) 2 ; and R 4 is selected from the group consisting of H, lower alkyl, amino, benzyl, halogen, --OH, --CH 2 COOH, --CH 2 PO 3 H 2 or --CH 2 CH 2 PO 3 H 2 .