Patent US4282161A successfully refreshed from Google Patents.
US4282161A
Expired / Lapsed
US
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Novel purification process
Assignee: Sanofi Aventis France
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Filing: 1980-05-05
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Granted: 1981-08-04
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Expires: 2000-05-05
Abstract
Abstract A novel process for the purification of ursodesoxycholic acid comprising reacting an aqueous solution of an alkali metal salt of ursodesoxycholic acid in the presence of chloroform with an acid and recovering crystalline ursodesoxycholic acid.
Inventors
- 👤 Armand Guillemette
- 👤 Abel Francois
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 09:13
CPC Classifications
C; C07; C07J; C07J9/00; C07J9/005
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
34 words
A process for the purification of ursodesoxycholic acid comprising reacting an aqueous solution of an alkali metal salt of ursodesoxycholic acid in the presence of chloroform with an acid and recovering crystalline ursodesoxycholic acid.
Claim 2
Dependent Claim
34 words
A process for the purification of ursodesoxycholic acid comprising reacting an aqueous solution of an alkali metal salt of ursodesoxycholic acid in the presence of chloroform with an acid and recovering crystalline ursodesoxycholic acid.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein the alkali metal salt is sodium salt.
Claim 4
Dependent Claim
14 words
The process of claim 1 wherein the alkali metal salt is the lithium salt.
Claim 5
Dependent Claim
11 words
The process of claim 1 wherein the acid is hydrochloric acid.
Claim 6
Dependent Claim
12 words
The process of claim 1 wherein the crystalline ursodesoxycholic acid is dried.
Claim 7
Dependent Claim
40 words
The process of claim 1 wherein the alkali metal salt of ursodesoxycholic acid is obtained by esterification of raw ursodesoxycholic acid with methanol, crystallizing the resulting methyl ester from ethyl acetate and saponifying the ester with an alkali metal base.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-03 | 1985-02-02 | 1985-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-03 | 1989-02-02 | 1989-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-03 | 1993-02-02 | 1993-08-04 | $7700.00 | Window Closed / Lapsed |