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US4281118A Expired / Lapsed US ⏱️ 0.0 years remaining

Aminoalkylsulfides, aminoalkylsulfoxides, and aminoalkylsulfones

Assignee: Dow Chemical Co
•
Filing: 1979-06-18
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Granted: 1981-07-28
•
Expires: 1999-06-18
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Abstract

Abstract Novel aminoalkylsulfides, aminoalkylsulfoxides and aminoalkylsulfones of the general formula ##STR1## wherein y and z independently represent the integer 0, 1 or 2; a represents the integer 0 or 2; n represents the integer 1, 2, 3 or 4; R 1 independently represent lower alkyl or hydrogen or alternatively R 1 and R 2 taken together with the adjacent nitrogen atom represent a 5 or 6 membered heterocyclic ring which may optionally contain an oxygen atom whereby a morpholino, piperidino, or pyrrolidino grouping is formed; R 3 represents halo such as chloro or bromo, lower alkylthio, arloweralkylthio, arylthio such as 4-methylphenylthio, 4-morpholinylloweralkylthio such as 4-morpholinylpropylthio, lower alkyl or arloweralkylamino such as 4-methoxybenzenemethanamino; R 4 represents hydrogen or lower alkyl. The invention also includes the pharmaceutically-acceptable salts of the compounds described herein.

Inventors

  • 👤 Joseph E. Dunbar
  • 👤 Louis E. Begin

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 05:42
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 65 words
A compound of the formula ##STR6## wherein y and z independently represent the integer 0, 1 or 2; a represents the integer 0; n represents the integer 1, 2, 3 or 4; R 1 and R 2 taken together with the adjacent nitrogen atom represent morpholino; R 3 represents halo, 4-morpholinylloweralkylthio, or lower alkyl; R 4 represents hydrogen and further including the pharmaceutically-acceptable salts thereof.
Claim 2
Dependent Claim 65 words
A compound of the formula ##STR6## wherein y and z independently represent the integer 0, 1 or 2; a represents the integer 0; n represents the integer 1, 2, 3 or 4; R 1 and R 2 taken together with the adjacent nitrogen atom represent morpholino; R 3 represents halo, 4-morpholinylloweralkylthio, or lower alkyl; R 4 represents hydrogen and further including the pharmaceutically-acceptable salts thereof.
Claim 3
Dependent Claim 13 words
The compound of claim 1 which is 4,4'-((4-chloro-1,3-phenylene)bis(thio-2,1-ethanediyl))bismorpholine or a pharmaceutically-acceptable salt thereof.
Claim 4
Dependent Claim 13 words
The compound of claim 1 which is 4,4'-((4-chloro-1,3-phenylene)bis(sulfonyl-2,1-ethanediyl))bismorpholine or a pharmaceutically-acceptable salt thereof.
Claim 5
Dependent Claim 13 words
The compound of claim 1 which is 4,4'-((4-chloro-1,3-phenylene)bis(thio-3,1-propanediyl))bismorpholine or a pharmaceutically-acceptable salt thereof.
Claim 6
Dependent Claim 13 words
The compound of claim 1 which is 4,4'-((4-chloro-1,3-phenylene)bis(sulfonyl-3,1-propanediyl)bismorpholine or a pharmaceutically-acceptable salt thereof.
Claim 7
Dependent Claim 13 words
The compound of claim 1 which is 4,4'-((4-methyl-1,2-phenylene)bis(thio-3,1-propanediyl))bismorpholine or a pharmaceutically-acceptable salt thereof.
Claim 8
Dependent Claim 13 words
The compound of claim 1 which is 4-(3-((2-chloro-5-(3-((4-morpholinyl)propyl(sulfonyl)phenyl)sulfinyl)propyl)morpholine or a pharmaceutically-acceptable salt thereof.
Claim 9
Dependent Claim 13 words
The compound of claim 1 which is 4,4'-((4-((3-(4-morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine or a pharmaceutically-acceptable salt thereof.

References Cited (Backward Citations)

US2659756A Cited
US4134996A Cited
US4141983A Cited
US4155907A Cited
BE865063A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1984-07-27 1985-01-26 1985-07-28 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1988-07-27 1989-01-26 1989-07-28 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1992-07-27 1993-01-26 1993-07-28 $7700.00 Window Closed / Lapsed

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