US4134996A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for inhibiting adp-induced platelet aggregation using phenylthioalkylamines
Assignee: Dow Chemical Co
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Filing: 1977-09-14
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Granted: 1979-01-16
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Expires: 1997-09-14
Abstract
Abstract A method for inhibiting blood platelet aggregation in a mammal by administering internally to the mammal an effective amount of a phenylthio(sulfinyl or sulfonyl)alkylamine compound or a pharmaceutically-acceptable salt thereof.
Inventors
- 👤 Joseph E. Dunbar
- 👤 Louis E. Begin
- 👤 Robert J. Broersma
- 👤 George D. Dickerson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:12
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
131 words
A method for inhibiting ADP-induced platelet aggregation and treating thrombosis in a mammal in need thereof comprising administering internally to said mammal a platelet aggregation inhibiting amount of a compound corresponding to the formula: ##STR3## and the pharmaceutically-acceptable salts thereof wherein: R 1 is diloweralkylamino, dicycloalkylamino, or hexamethyleneimino; R 2 is lower alkyl or hydrogen; R 3 is lower alkyl, halo, hydroxy, amino, acetamino, acetoxy, lower alkoxy, or carboxy; r is an integer of from 0 to 5; x is an integer of from 0 to 2; y is an integer of from 0 to 4 with the proviso that when R 2 is lower alkyl, y is 1; and z is an integer of from 0 to 3 with the proviso that when R 2 is hydrogen z is 0.
Claim 2
Independent Claim
131 words
A method for inhibiting ADP-induced platelet aggregation and treating thrombosis in a mammal in need thereof comprising administering internally to said mammal a platelet aggregation inhibiting amount of a compound corresponding to the formula: ##STR3## and the pharmaceutically-acceptable salts thereof wherein: R 1 is diloweralkylamino, dicycloalkylamino, or hexamethyleneimino; R 2 is lower alkyl or hydrogen; R 3 is lower alkyl, halo, hydroxy, amino, acetamino, acetoxy, lower alkoxy, or carboxy; r is an integer of from 0 to 5; x is an integer of from 0 to 2; y is an integer of from 0 to 4 with the proviso that when R 2 is lower alkyl, y is 1; and z is an integer of from 0 to 3 with the proviso that when R 2 is hydrogen z is 0.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein R 1 of the compound is dimethylamino, diethylamino, dipropylamino, diisopropylamino, dibutylamino, dicyclohexylamino, and hexamethyleneimino.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein R 3 of the compound is lower alkyl, lower alkoxy, and hydroxy.
Claim 5
Dependent Claim
9 words
The method of claim 1 wherein x is 2.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein the compound is 2-(diethylamino)ethyl phenyl sulfide and the pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
18 words
The method of claim 1 wherein the compound is 3-(dimethylamino)propyl phenyl sulfide and the pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
16 words
The method of claim 1 wherein the compound is 2-(2-diisopropylamino)ethylthio)-1,4-hydroquinone and the pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
16 words
The method of claim 1 wherein the compound is 2-(2-(diethylamino)ethylthio)-3,6-dimethyl-1,4-hydroquinone and the pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
GB1371650A
Cited
US3988475A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-15 | 1982-07-17 | 1983-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-15 | 1986-07-17 | 1987-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-15 | 1990-07-17 | 1991-01-16 | $7700.00 | Window Closed / Lapsed |