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US4281065A
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US
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Phencyclidine conjugates to antigenic proteins and enzymes
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1979-01-25
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Granted: 1981-07-28
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Expires: 1999-01-25
Abstract
Abstract Phencylidine, PCP, derivatives having a non-oxo carbonyl functionality linked directly or through a linking group to the phenyl ring are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of phencyclidine, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of phencyclidine.
Inventors
- 👤 Cheng-I Lin
- 👤 Prithipal Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 19:55
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/096; C07D295/14; C07D295/155; C12; C12N; C12N9/00; C12N9/96; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/535; G01N33/94; G01N33/9486; Y; Y10; Y10S; Y10S436/00; Y10S436/815; Y10S436/823; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
71 words
Compound of the formula: ##STR5## wherein: A is 1-(N piperidyl)cyclohexyl-1; φ is p-phenylene; R is a divalent aliphatic group of from 2 to 6 carbon atoms and 0 to 1 oxygen atom bonded solely to aliphatically saturated carbon atoms; Y is oxygen; m 2 is one; Z 2 is a poly(amino acid); n 2 is at least one and not greater than the molecular weight of Z 2 divided by 500.
Claim 2
Dependent Claim
71 words
Compound of the formula: ##STR5## wherein: A is 1-(N piperidyl)cyclohexyl-1; φ is p-phenylene; R is a divalent aliphatic group of from 2 to 6 carbon atoms and 0 to 1 oxygen atom bonded solely to aliphatically saturated carbon atoms; Y is oxygen; m 2 is one; Z 2 is a poly(amino acid); n 2 is at least one and not greater than the molecular weight of Z 2 divided by 500.
Claim 3
Dependent Claim
22 words
Compound according to claim 1, wherein Z 2 is an enzyme, and n 2 is in the range of 2 to 16.
Claim 4
Dependent Claim
11 words
Compound according to claim 2, wherein said enzyme is glucose-6-phosphate dehydrogenase.
Claim 5
Dependent Claim
23 words
Compound according to claim 1, wherein Z 2 is an antigen, and n 2 is in the range of about 2 to 500.
Claim 6
Dependent Claim
10 words
Compound according to claim 4, wherein said antigen is globulin.
Claim 7
Dependent Claim
11 words
Compound according to claim 4 wherein said antigen is an albumin.
Claim 8
Dependent Claim
11 words
Conjugate of 5-(4'-(1"-(N-piperidino)cyclohexyl-1")phenyl-1')-3-oxapentanoic acid with glucose-6-phosphate dehydrogenase connected by amide bonds.
Claim 9
Dependent Claim
11 words
Conjugate of 5-(4'-(1"-(N-piperidino)cyclohexyl-1")phenyl-1')-3-oxapentanoic acid with glucose-6-phosphate dehydrogenase connected by amide bonds.
Claim 10
Dependent Claim
13 words
Conjugate of 5-(4'-(1"-(N-piperidino)cyclohexyl-1")phenyl-1')-3-oxapentanoic acid with a poly(amino acid) antigen connected by amide bonds.
Claim 11
Dependent Claim
13 words
Conjugate of 5-(4'-(1"-(N-piperidino)cyclohexyl-1")phenyl-1')-3-oxapentanoic acid with a poly(amino acid) antigen connected by amide bonds.
Claim 12
Dependent Claim
11 words
Conjugate according to claim 8, wherein said antigen is a globulin.
Claim 13
Dependent Claim
11 words
Conjugate according to claim 8, wherein said antigen is an albumin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-27 | 1985-01-26 | 1985-07-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-27 | 1989-01-26 | 1989-07-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-27 | 1993-01-26 | 1993-07-28 | $7700.00 | Window Closed / Lapsed |