Patent US4279991A successfully refreshed from Google Patents.
US4279991A
Expired / Lapsed
US
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Process and apparatus for preparing multi-component reagent solutions
Assignee: Roche Diagnostics GmbH
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Filing: 1979-12-04
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Granted: 1981-07-21
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Expires: 1999-12-04
Abstract
Abstract The invention provides a process for the production of reagent solutions containing a plurality of components for analytical purposes, wherein the individual components of several differently composed reagents are each introduced into a solid, proportionable carrier material in easily redissolvable form in such an amount that each part by volume or weight of the carrier material carries a definite amount of one reagent component, the carriers of the components are brought together in a magazine-like manner and, for the production of a particular reagent, from all carriers which carry a component of the reagent, there are simultaneously taken off the amounts corresponding to the required amounts of the components, which are then dissolved to form the reagent solution. Apparatus for carrying out the process is also provided.
Inventors
- 👤 Alexander Hagen
- 👤 Hermann Edelmann
- 👤 Sigmar Klose
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:52
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/00009; C; C12; C12Q; C12Q1/00; G01N31/00; G01N31/22; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/521; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10T; Y10T83/00; Y10T83/162; Y10T83/166; Y10T83/169; Y10T83/202; Y10T83/2066; Y10T83/889; Y10T83/896; Y10T83/902
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
79 words
A process for the preparation of a multi-component reagent solution, comprising: providing each of a plurality of individual reagent components in a redissolvable form on a separate solid carrier capable of being formed into discrete sub-elements carrying a defined amount of a reagent component of said plurality of reagent components; simultaneously forming sub-elements from at least one solid carrier; and introducing the sub-elements into a common reagent solvent to dissolve the associated reagent components and form the reagent solution.
Claim 2
Dependent Claim
79 words
A process for the preparation of a multi-component reagent solution, comprising: providing each of a plurality of individual reagent components in a redissolvable form on a separate solid carrier capable of being formed into discrete sub-elements carrying a defined amount of a reagent component of said plurality of reagent components; simultaneously forming sub-elements from at least one solid carrier; and introducing the sub-elements into a common reagent solvent to dissolve the associated reagent components and form the reagent solution.
Claim 3
Dependent Claim
25 words
A process as claimed in claim 1 wherein said carrier comprises paper or film the required amount of which is cut off or punched out.
Claim 4
Dependent Claim
28 words
A process as claimed in claim 1 wherein the carrier is particular material with an absorbent surface layer and the required amounts being measured volumetrically or by counting.
Claim 5
Dependent Claim
26 words
A process as claimed in claim 1 wherein said individual components are selected from enzymes, co-enzymes, substrates, salts, buffer substrates, indicator substances, surface-active substances and adjuvants.
Claim 6
Dependent Claim
29 words
A process as claimed in claim 1 wherein said components are introduced into said carrier by applying a solution of the component to the carrier and then drying same.
Claim 7
Dependent Claim
16 words
A process as claimed in claim 5 wherein the components are dissolved in an organic solvent.
Claim 8
Dependent Claim
13 words
A process as claimed in claim 1 wherein said reagent solvent is water.
Claim 9
Dependent Claim
87 words
Apparatus for the preparation of reagent solutions for analytical purposes containing a plurality of individual components which apparatus comprises a magazine containing a plurality of carrier materials each of which carries, per unit volume or weight, a defined amount of an individual reagent component, a proportioning device capable of measuring and separating off defined amounts from several carrier materials, conveyor means for transporting the separated-off amounts of carrier to a solvent container, and control means which actuates and controls said proportioning device for any specific reagent composition.
Claim 10
Dependent Claim
87 words
Apparatus for the preparation of reagent solutions for analytical purposes containing a plurality of individual components which apparatus comprises a magazine containing a plurality of carrier materials each of which carries, per unit volume or weight, a defined amount of an individual reagent component, a proportioning device capable of measuring and separating off defined amounts from several carrier materials, conveyor means for transporting the separated-off amounts of carrier to a solvent container, and control means which actuates and controls said proportioning device for any specific reagent composition.
Claim 11
Dependent Claim
28 words
Apparatus as claimed in claim 8 wherein said proportioning device is capable of measuring and separating off defined amounts of carrier materials from more than one carrier material.
Claim 12
Dependent Claim
73 words
Apparatus as claimed in claim 8 wherein said carrier materials are in the form of a roll of paper strip, said magazine includes openings for outputting the strips and said proportioning device comprises paper advancing means, controlled by the control device, adapted to advance defined lengths of the paper strip through the magazine openings, and a cutting device for each advancing means for cutting off lengths of strip emerging from the magazine openings.
Claim 13
Dependent Claim
23 words
Apparatus as claimed in claim 10 wherein said magazine comprises a housing and cassettes insertably arranged therein, each cassette containing a carrier strip.
Claim 14
Dependent Claim
25 words
Apparatus as claimed in claim 10 wherein said cutting device is capable of cutting off simultaneously lengths of several strips emerging from said magazine openings.
Claim 15
Dependent Claim
28 words
Apparatus as claimed in claim 10 wherein the conveyor means includes a conveyor device comprising a conveyor band adapted to transport separated carrier materials to the solvent container.
Claim 16
Dependent Claim
18 words
Apparatus as claimed in claim 13 wherein said conveyor means further comprises a wind tunnel and a blower.
Claim 17
Dependent Claim
30 words
Apparatus as claimed in claim 14 wherein said wind tunnel is connected with the magazine housing in a manner that the magazine openings are operatively connected to the wind tunnel.
Claim 18
Dependent Claim
23 words
Apparatus as claimed in claim 10 wherein said push-forward device comprises a toothed wheel which engages a corresponding perforation in the carrier strip.
Claim 19
Dependent Claim
31 words
Apparatus as claimed in claim 10 wherein the proportioning device comprises a punch which is adapted to cut out from the carrier strip a predetermined number of pieces of equal size.
Claim 20
Dependent Claim
19 words
Apparatus as claimed in claim 10 wherein the solvent container comprises a cuvette made of an optically clear material.
Claim 21
Dependent Claim
25 words
Apparatus as claimed in claim 18 wherein said cuvette contains a rod-shaped member of adjustable height the lower end of which carries a sieve-like plunger.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-20 | 1985-01-19 | 1985-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-20 | 1989-01-19 | 1989-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-20 | 1993-01-19 | 1993-07-21 | $7700.00 | Window Closed / Lapsed |