US4277607A
Expired / Lapsed
US
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Process for the preparation of 4-chloroquinolines
Assignee: Sanofi Aventis France
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Filing: 1978-09-15
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Granted: 1981-07-07
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Expires: 1998-09-15
Abstract
Abstract Novel process for the preparation of 4-chloroquinolines of the formula ##STR1## wherein X is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, methyl, halogen, CF 3 --, CF 3 O-- and CF 3 S-- by reacting a compound of the formula ##STR2## or a functional derivative thereof with a chlorination agent in the presence of an oxidation agent and to a novel intermediate.
Inventors
- 👤 Jacques Bulidon
- 👤 Charles Pavan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 01:13
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/18
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
92 words
A process for the preparation of 4-chloro-quinolines of the formula ##STR8## wherein X is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, methyl, halogen, CF 3 --, CF 3 O-- and CF 3 S-- consisting essentially of reacting an acid of the formula ##STR9## with a chlorination agent selected from the group consisting of phosphorus oxychloride, phosphorus pentachloride and thionyl chloride in the presence of an oxidation agent selected from the group consisting of oxygen, iodine, cupric chloride and ferric chloride to form the desired compound.
Claim 2
Dependent Claim
92 words
A process for the preparation of 4-chloro-quinolines of the formula ##STR8## wherein X is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, methyl, halogen, CF 3 --, CF 3 O-- and CF 3 S-- consisting essentially of reacting an acid of the formula ##STR9## with a chlorination agent selected from the group consisting of phosphorus oxychloride, phosphorus pentachloride and thionyl chloride in the presence of an oxidation agent selected from the group consisting of oxygen, iodine, cupric chloride and ferric chloride to form the desired compound.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein the starting material has the formula ##STR10##
Claim 4
Dependent Claim
11 words
The process of claim 1 wherein X is CF 3 --.
Claim 5
Dependent Claim
12 words
The process of claim 1 wherein the chlorination agent is phosphorus oxychloride.
Claim 6
Dependent Claim
11 words
The process of claim 1 wherein the oxidation agent is iodine.
Claim 7
Dependent Claim
18 words
The process of claim 1 wherein the chlorination agent is phosphorus oxychloride and the oxidation agent is iodine.
Claim 8
Dependent Claim
18 words
The process of claim 1 wherein β-(o-trifluoromethylanilino)-propanoic acid is reacted with phosphorus oxychloride in the presence of iodine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-06 | 1985-01-05 | 1985-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-06 | 1989-01-05 | 1989-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-06 | 1993-01-05 | 1993-07-07 | $7700.00 | Window Closed / Lapsed |