Process for the preparation of chlorinated quinolines
Abstract
Abstract THIS INVENTION RELATES TO A PROCESS FOR THE PREPARATION OF CHLORINATED QUINOLINES OF THE FORMULA 4-CL,CL-QUINOLINE WHEREIN THE CHLORINE ATTACHED TO THE BENZENE NUCLEUS IS IN A POSITION SELECTED FROM THE GROUP CONSISTING OF THE 5, 6, 7 AND 8 POSITIONS. THE SAID PROCESS INVOLVES REACTING A 2, 3 OR 4-CHLOROANILINE WITH A COMPOUND SELECTED FROM THE GROUP CONSISTING OF B-PROPIOLACTONE AND A COMPOUND OF THE FORMULA CH2=CH-COOR WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL, CYCLIZING THE 3-(CHLOROANILINO)PROPIONIC ACID FORMED WITH POLYPHOSPHORIC ACID, CHLORINATING THE RESULTING 5, 6, 7 OR 8-CHLORO-4-OXO-1,2,3,4TETRAHYDROQUINOLINE WITH PHOSPHORUS OXYCHLORIDE AND RECOVERING SAID CHLORINATED QUINOLINE. THE DICHLOROQUINOLINES ARE KNOWN PRODUCTS USEFUL AS INTERMEDIATES IN THE PRODUCTION OF KNOWN COMPOUNDS HAVING THERAPEUTIC ACTIVITY.
Inventors
- 👤 Robert Joly
- 👤 Julien Warnant
- 👤 Bernard Goffinet
Bibliographic Details
Claims Analysis
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1974-03-01 | 1974-08-31 | 1975-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-03-01 | 1978-08-31 | 1979-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-03-01 | 1982-08-31 | 1983-03-02 | $7700.00 | Window Closed / Lapsed |