Patent US4277238A successfully refreshed from Google Patents.
US4277238A
Expired / Lapsed
US
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Artificial bonelike graft and method for producing the same
Assignee: Individual
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Filing: 1979-03-30
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Granted: 1981-07-07
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Expires: 1999-03-30
Abstract
Abstract An artificial bonelike graft is disclosed. The graft of this invention comprises a biological material such as a bone piece and tooth taken from an animal or a human, which material is decalcified and defatted. Upon implanting the graft, it will be assimilated with the existing tissues and become a part of the living organs. A method for producing such grafts is also disclosed.
Inventors
- 👤 Masataka Katagiri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 12:32
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3695; A61C; A61C8/00; A61C8/0012; A61L27/3604; A61L27/3608; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
75 words
A method for producing an artificial bonelike graft comprising the steps of: (a) fixing a bonelike piece taken from a mammal with a fixing agent selected from the group consisting of formalin, alcohol and paraformaldehyde, (b) decalcifying said piece with a decalcifying agent comprising an acid selected from the group consisting of formic acid, hydrochloric acid, nitric acid, oxalic acid and citric acid, (c) defatting said piece with alcohol, and (d) freeze drying said piece.
Claim 2
Independent Claim
75 words
A method for producing an artificial bonelike graft comprising the steps of: (a) fixing a bonelike piece taken from a mammal with a fixing agent selected from the group consisting of formalin, alcohol and paraformaldehyde, (b) decalcifying said piece with a decalcifying agent comprising an acid selected from the group consisting of formic acid, hydrochloric acid, nitric acid, oxalic acid and citric acid, (c) defatting said piece with alcohol, and (d) freeze drying said piece.
Claim 3
Dependent Claim
28 words
A method for producing an artificial bonelike graft according to claim 1, wherein before said freeze drying step, said piece is washed with water and dehydrated with alcohol.
Claim 4
Independent Claim
73 words
A method for producing an artificial bonelike graft comprising the steps of: (a) fixing a bonelike piece taken from a mammal with a fixing agent selected from the group consisting of formalin, alcohol and paraformaldehyde, (b) decalcifying said piece with a decalcifying agent selected from the group consisting of formic acid, hydrochloric acid, nitric acid, oxalic acid, citric acid, and ethylenediaminetetraacetate, (c) defatting said piece with alcohol, and (d) freeze drying said piece.
Claim 5
Independent Claim
73 words
A method for producing an artificial bonelike graft comprising the steps of: (a) fixing a bonelike piece taken from a mammal with a fixing agent selected from the group consisting of formalin, alcohol and paraformaldehyde, (b) decalcifying said piece with a decalcifying agent selected from the group consisting of formic acid, hydrochloric acid, nitric acid, oxalic acid, citric acid, and ethylenediaminetetraacetate, (c) defatting said piece with alcohol, and (d) freeze drying said piece.
Claim 6
Dependent Claim
22 words
The method of claim 3 wherein said bonelike graft is a biological material selected from the group consisting of bone and teeth.
Claim 7
Dependent Claim
22 words
The method of claim 3 wherein prior to said freeze drying step, said piece is washed with water and dehydrated with alcohol.
Claim 8
Dependent Claim
21 words
The method of claim 3 wherein said fixing agent is formalin and is diluted to a strength from 5% to 30%.
Claim 9
Dependent Claim
22 words
The method of claim 3 wherein said decalcifying agent is an acid and is diluted to a strength from 3% to 10%.
Claim 10
Dependent Claim
35 words
The method of claim 3 wherein said alcohol used in said defatting step is selected from the group consisting of ethyl alcohol and butyl alcohol, and is diluted to a strength from 50% to 80%.
Claim 11
Dependent Claim
18 words
The method of claim 3 wherein said defatting step (c) is performed subsequent to said decalcifying step (b).
Claim 12
Dependent Claim
18 words
The method of claim 3 wherein said defatting step (c) is performed prior to said decalcifying step (b).
Claim 13
Dependent Claim
25 words
The method of claim 3 wherein said defatting step (c) is performed simultaneously with said fixing step (a) and wherein said fixing agent is alcohol.
Claim 14
Dependent Claim
19 words
The method of claim 3 comprising the further step of: (e) treating said piece with an antibacterial sterilizing agent.
Claim 15
Independent Claim
58 words
A method for producing an artificial bonelike graft from a biological material selected from the group consisting of bone and teeth comprising the steps of fixing the material with 5% to 30% formalin, decalcifying the material with 3% to 10% acid, defatting the material with 50% to 80% alcohol and freeze drying the material at below 4° C.
Claim 16
Independent Claim
58 words
A method for producing an artificial bonelike graft from a biological material selected from the group consisting of bone and teeth comprising the steps of fixing the material with 5% to 30% formalin, decalcifying the material with 3% to 10% acid, defatting the material with 50% to 80% alcohol and freeze drying the material at below 4° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-06 | 1985-01-05 | 1985-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-06 | 1989-01-05 | 1989-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-06 | 1993-01-05 | 1993-07-07 | $7700.00 | Window Closed / Lapsed |