Cellulose acetate hollow fiber and method for making same

Claim 2

A cellulose acetate hollow fiber having an internal diameter in the range of about 100 to about 350 microns and a wall thickness in the range of about 20 to about 60 microns, said wall having a selective permeability when used in hemodialysis for water and solutes to be removed from blood represented by an ultrafiltration coefficient K UFR in the range of about 2 to about 6 milliliters per hour per square meter per millimeter of mercury and a urea coefficient K UREA in the range of about 15×10 -3 to about 45×10 -3 centimeters per minute, said fiber characterized by the concurrent capability of separating urea from blood and water from blood at rates represented by a minimum ratio of the coefficients K UREA /K UFR of 3 to 1×10 -3 .

Claim 3

A cellulose acetate hollow fiber having an internal diameter in the range of about 100 to about 350 microns and a wall thickness in the range of about 20 to about 60 microns, said wall having a selective permeability when used in hemodialysis for water and solutes to be removed from blood represented by an ultrafiltration coefficient K UFR in the range of about 2 to 6 milliliters per hour per square meter per millimeter of mercury, a urea coefficient K UREA in the range of about 15×10 -3 to about 45×10 -3 centimeters per minute, and a creatinine coefficient K creatinine in the range of about 13×10 -3 to about 27×10 -3 centimeters per minute, said fiber characterized by the concurrent capability of separating urea from blood and water from blood at rates represented by a minimum ratio of the coefficients K UREA /K UFR of 3 to 1×10 -3 .

Claim 4

A cellulose acetate hollow fiber having an internal diameter in the range of about 100 to about 350 microns and a wall thickness in the range of about 20 to about 60 microns, said wall having a selective permeability when used in hemodialysis for water and solutes to be removed from blood represented by an ultrafiltration coefficient K UFR in the range of about 2 to 6 milliliters per hour per square meter per millimeter of mercury, a urea coefficient K UREA in the range of about 15×10 -3 to about 45×10 -3 centimeters per minute, and a creatinine coefficient K creatinine in the range of about 13×10 -3 to about 27×10 -3 centimeters per minute, said fiber characterized by the concurrent capability of separating urea from blood and water from blood at rates represented by a minimum ratio of the coefficients K UREA /K UFR of 3 to 1×10 -3 .

Claim 5

A cellulose acetate hollow fiber having an internal diameter in the range of about 100 to about 350 microns and a wall thickness in the range of about 20 to 60 microns, said wall having a selective permeability when used in hemodialysis for water and solutes to be removed from blood represented by an ultrafiltration coefficient K UFR in the range of about 2 to 6 milliliters per hour per square meter per millimeter of mercury, a urea coefficient K UREA in the range of about 15×10 -3 to about 45×10 -3 centimeters per minute, a creatinine coefficient K creatinine in the range ofabout 13×10 -3 to about 27×10 -3 centimeters per minute and a Vitamin B 12 coefficient K B12 in the range of about 2×10 -3 to about 5×10 -3 centimeters per minute, said fiber characterized by the concurrent capability of separating urea from blood and water from blood at rates represented by a minimum ratio of the coefficients K UREA /K UFR of 3 to 1×10 -3 .

Claim 6

A cellulose acetate hollow fiber having an internal diameter in the range of about 100 to about 350 microns and a wall thickness in the range of about 20 to 60 microns, said wall having a selective permeability when used in hemodialysis for water and solutes to be removed from blood represented by an ultrafiltration coefficient K UFR in the range of about 2 to 6 milliliters per hour per square meter per millimeter of mercury, a urea coefficient K UREA in the range of about 15×10 -3 to about 45×10 -3 centimeters per minute, a creatinine coefficient K creatinine in the range ofabout 13×10 -3 to about 27×10 -3 centimeters per minute and a Vitamin B 12 coefficient K B12 in the range of about 2×10 -3 to about 5×10 -3 centimeters per minute, said fiber characterized by the concurrent capability of separating urea from blood and water from blood at rates represented by a minimum ratio of the coefficients K UREA /K UFR of 3 to 1×10 -3 .

Claim 7

A fiber in accordance with claim 1, wherein said ultrafiltration coefficient K UFR is in the range of about 5 to about 6 and said urea coefficient K UREA is in the range of about 30×10 -3 to about 45×10 -3 , and wherein said minimum ratio of K UREA /K UFR is 5 to 1×10 -3 .

Claim 8

A fiber in accordance with claim 2, wherein said creatinine coefficient K creatinine is in the range of about 20×10 -3 to about 27×10 -3 , and wherein said minimum ratio of K UREA /K UFR is 5 to 1×10 -3 .

Claim 9

A process for making cellulose acetate hollow fibers which comprises the steps of (1) providing an intimate mixture of about 41 to about 50 weight percent cellulose acetate, about 2 to about 20 weight percent glycerine, and about 30 to about 57 percent polyethylene glycol having a molecular weight in the range of about 150 to about 600, (2) fabricating hollow fibers from a molten mass of said mixture, (3) cooling said fibers, (4) cold drawing said fibers an amount in the range of about 2% to about 20% of said cooled fiber length, (5) leaching said fiber to remove therefrom said polyethylene glycol and said glycerine, and (6) replasticizing said fiber with glycerine and thereafter drying same.

Claim 10

A process for making cellulose acetate hollow fibers which comprises the steps of (1) providing an intimate mixture of about 41 to about 50 weight percent cellulose acetate, about 2 to about 20 weight percent glycerine, and about 30 to about 57 percent polyethylene glycol having a molecular weight in the range of about 150 to about 600, (2) fabricating hollow fibers from a molten mass of said mixture, (3) cooling said fibers, (4) cold drawing said fibers an amount in the range of about 2% to about 20% of said cooled fiber length, (5) leaching said fiber to remove therefrom said polyethylene glycol and said glycerine, and (6) replasticizing said fiber with glycerine and thereafter drying same.

Claim 11

A process in accordance with claim 6 wherein said cellulose acetate in said mixture is in the range of about 42 to about 47 weight percent.

Claim 12

A process in accordance with claim 6 wherein said cold drawing is an amount in the range of about 10 to about 15% of the length of said cooled fiber.