Patent US4273933A successfully refreshed from Google Patents.
US4273933A
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Modified catalyst for stereo-differentiating reduction of _carbonyl compounds and process for reduction with same catalyst
Assignee: Kawaken Fine Chemicals Co Ltd
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Filing: 1979-04-25
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Granted: 1981-06-16
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Expires: 1999-04-25
Abstract
Abstract A modified nickel catalyst used for stereo-differentiating reduction of carbonyl compounds is provided. The modified nickel catalyst is prepared by soaking a nickel catalyst in an aqueous modifying medium having dissolved therein at least one inorganic salt, such as sodium bromide or sodium chloride, and at least one optically active substance, such as optically active hydroxy acid. The modified nickel catalyst exhibits enhanced activity for stereo-differentiating reduction and causes little or no side reactions, and thus, brings about an extremely high yield of the reaction product.
Inventors
- 👤 Tadao Harada
- 👤 Yoshiharu Izumi
- 👤 Shinichiro Komatsu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 18:23
CPC Classifications
B; B01; B01J; B01J23/00; B01J23/70; B01J23/74; B01J23/755; C; C07; C07C; C07C29/00; C07C29/132; C07C29/136; C07C29/143; C07C29/145; C07B; C07B2200/00; C07B2200/07
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
118 words
A process for stereo-differentially reducing a carbonyl compound, wherein the carbonyl compound is contacted with a modified nickel catalyst prepared by soaking a nickel catalyst in an aqueous modifying medium having dissolved therein at least one optically active substance selected from the group consisting of optically active hydroxycarboxylic acids and optically active amino acids, and, then, separating the so-treated catalyst from the aqueous modifying medium, characterized in that the aqueous modifying medium has dissolved therein, in addition to the optically active substance, at least one inorganic salt said inorganic salt being contained in the modifying medium in an amount of from 0.006 to 25 times, by weight, based on the amount of metallic nickel in said nickel catalyst.
Claim 2
Dependent Claim
118 words
A process for stereo-differentially reducing a carbonyl compound, wherein the carbonyl compound is contacted with a modified nickel catalyst prepared by soaking a nickel catalyst in an aqueous modifying medium having dissolved therein at least one optically active substance selected from the group consisting of optically active hydroxycarboxylic acids and optically active amino acids, and, then, separating the so-treated catalyst from the aqueous modifying medium, characterized in that the aqueous modifying medium has dissolved therein, in addition to the optically active substance, at least one inorganic salt said inorganic salt being contained in the modifying medium in an amount of from 0.006 to 25 times, by weight, based on the amount of metallic nickel in said nickel catalyst.
Claim 3
Dependent Claim
25 words
A process according to claim 1, wherein the stereo-differentiating reduction of a carbonyl compound is effected at a temperature of from 50° to 120° C.
Claim 4
Dependent Claim
32 words
A process according to claim 1, wherein the stereo-differentiating reduction of a carbonyl compound is effected at an atmospheric pressure or a superatmospheric pressure of not higher than 150 kg/cm 2 .
Claim 5
Dependent Claim
180 words
A process according to claim 1, wherein the carbonyl compound is selected from the compounds represented by the general formulae (I), (II), (III) and (IV): ##STR3## wherein each of R 1 , R 2 , R 3 and R 4 is a substituted or unsubstituted alkyl group having 1 to 12 carbon atoms, a substituted or unsubstituted aryl group having 6 to 14 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 15 carbon atoms or a substituted or unsubstituted alkylaryl group having 7 to 17 carbon atoms, R 1 and R 2 are different from each other and may form together a ring, and R 3 and R 4 may be identical to or different from each other and may form together a ring; R 5 is a hydroxyl group or a substituted or unsubstituted alkoxy group having 1 to 12 carbon atoms, and; R 0 is a straight-chain or branched alkylene group having 1 to 6 carbon atoms or a straight-chain alkylene group having a hydroxyl group or groups and having 1 to 6 carbon atoms.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-06-15 | 1984-12-15 | 1985-06-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-06-15 | 1988-12-15 | 1989-06-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-06-15 | 1992-12-15 | 1993-06-16 | $7700.00 | Window Closed / Lapsed |