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US4272328A
Expired / Lapsed
US
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Buffer overcoat for CO2 ion-selective electrodes
Assignee: Clinical Diagnostic Systems Inc
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Filing: 1979-12-05
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Granted: 1981-06-09
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Expires: 1999-12-05
Abstract
Abstract An ion-selective electrode for analyzing CO 2 concentration in a liquid sample comprises a support having thereon a metal zone, a metal halide zone, an electrolyte zone, a zone comprising a membrane comprising an ionophore and a zone comprising a hydrophilic binder and a buffer in an amount sufficient to provide a solution having a pH in the range of about 7.5 to 9.5 when wetted with about 5 μl of liquid.
Inventors
- 👤 Sang H. Kim
- 👤 Hao-jan Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:11
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/333; G01N27/3335
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
90 words
In an ion-selective electrode for analyzing CO 2 concentration in a liquid comprising a support having thereon a layer or layers having sequentially metal/metal halide reference electrode zones, an electrolyte zone and a membrane zone containing an ionophore, the improvement wherein said membrane zone is positioned between said electrolyte zone and an adjacent zone comprising a hydrophilic binder and a buffer in an amount sufficient to provide a solution having a pH in the range of 7.5 to 9.5 when wetted with about 5 μl of liquid to be analyzed.
Claim 2
Dependent Claim
90 words
In an ion-selective electrode for analyzing CO 2 concentration in a liquid comprising a support having thereon a layer or layers having sequentially metal/metal halide reference electrode zones, an electrolyte zone and a membrane zone containing an ionophore, the improvement wherein said membrane zone is positioned between said electrolyte zone and an adjacent zone comprising a hydrophilic binder and a buffer in an amount sufficient to provide a solution having a pH in the range of 7.5 to 9.5 when wetted with about 5 μl of liquid to be analyzed.
Claim 3
Dependent Claim
18 words
The ion-selective electrode of claim 1 wherein all of the zones are in one layer on the support.
Claim 4
Dependent Claim
13 words
The ion-selective electrode of claim 1 wherein each zone is a separate layer.
Claim 5
Dependent Claim
20 words
The ion-selective electrode of claim 3 wherein the metal/metal halide reference electrode layers are silver and silver halide layers, respectively.
Claim 6
Dependent Claim
11 words
The ion-selective electrode of claim 3 wherein the ionophore is 4'-alkyl-ααα-trifluoroacetophenone.
Claim 7
Dependent Claim
37 words
The ion-selective electrode of claim 1 wherein the buffer is present in an amount sufficient to provide a solution having a pH in the range of 7.5 to 9.5 when wetted with about 5 μl of serum.
Claim 8
Dependent Claim
23 words
The ion-selective electrode of claim 3 wherein the buffer comprises a member selected from the group consisting of tris(hydroxymethyl)aminomethane, diethanolamine, 2-amino-2-methyl-1,3-propanediol and 2-amino-2-ethyl-1,3-propanediol.
Claim 9
Dependent Claim
17 words
The ion-selective electrode of claim 3 wherein the layer containing said buffer solution also comprises a surfactant.
Claim 10
Dependent Claim
27 words
The ion-selective electrode of claim 3 wherein said hydrophilic binder is selected from the group consisting of gelatin, poly(vinyl alcohol) and poly(2-hydroxyethyl acrylate-co-sodium acrylate-co-N-isopropylacrylamide) (36:23:41 by weight).
Claim 11
Dependent Claim
85 words
In a process of preparing an ion-selective electrode for analyzing CO 2 concentration in a liquid comprising coating a support with, in succession, layers of metal, metal halide, electrolyte layer and a membrane layer comprising an ionophore, the improvement wherein the membrane layer is overcoated with a layer comprising a hydrophilic binder and a buffer in an amount sufficient to provide a solution having a pH in the range of from about 7.5 to 9.5 when wetted with 5 μl of liquid to be analyzed.
Claim 12
Dependent Claim
85 words
In a process of preparing an ion-selective electrode for analyzing CO 2 concentration in a liquid comprising coating a support with, in succession, layers of metal, metal halide, electrolyte layer and a membrane layer comprising an ionophore, the improvement wherein the membrane layer is overcoated with a layer comprising a hydrophilic binder and a buffer in an amount sufficient to provide a solution having a pH in the range of from about 7.5 to 9.5 when wetted with 5 μl of liquid to be analyzed.
Claim 13
Dependent Claim
11 words
The process of claim 10 wherein the metal layer comprises silver.
Claim 14
Dependent Claim
13 words
The process of claim 10 wherein the metal halide layer is silver chloride.
Claim 15
Dependent Claim
10 words
The process of claim 10 wherein the ionophore is 4'-alkyl-ααα-trifluoroacetophenone.
Claim 16
Dependent Claim
22 words
The process of claim 10 wherein the buffer comprises a member selected from the group consisting of tris(hydroxymethyl)aminomethane, diethanolamine, 2-amino-2-methyl-1,3-propanediol and 2-amino-2-ethyl-1,3-propanediol.
Claim 17
Dependent Claim
16 words
The process of claim 14 wherein the layer containing said buffer solution also comprises a surfactant.
Claim 18
Dependent Claim
26 words
The process of claim 10 wherein said hydrophilic binder is selected from the group consisting of gelatin, poly(vinyl alcohol) and poly(2-hydroxyethyl acrylate-co-sodium acrylate-co-N-isopropylacrylamide) (36:23:41 by weight).
Claim 19
Dependent Claim
37 words
The process of claim 10 wherein said buffer is present in an amount sufficient to provide a solution having a pH in the range of from about 7.5 to 9.5 when wetted with 5 μl of serum.
Claim 20
Dependent Claim
27 words
The process of assaying for CO 2 concentration in a liquid sample comprising contacting the sample with the buffer zone of the ion-selective electrode of claim 1.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-06-08 | 1984-12-08 | 1985-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-06-08 | 1988-12-08 | 1989-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-06-08 | 1992-12-08 | 1993-06-09 | $7700.00 | Window Closed / Lapsed |