US4271085A
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Cis-platinum (II) amine lactate complexes
Assignee: Engelhard Minerals and Chemicals Corp
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Filing: 1979-06-20
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Granted: 1981-06-02
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Expires: 1999-06-20
Abstract
Abstract Cis-Platinum(II) amine lactate complexes are prepared by reaction of the appropriate platinum(II) amine chloride complex with silver lactate. These complexes possess pronounced anti-tumor activity and low toxicity and thus have high therapeutic indices. They are also highly soluble in water.
Inventors
- 👤 Alan R. Amundsen
- 👤 Eric W. Stern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:24
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00; C07C; C07C59/00; C07C59/01; C07C59/08
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
53 words
A complex of the general formula: cis-[Pt(II)A.sub.2 (C.sub.3 H.sub.5 O.sub.3).sub.2 ] wherein the platinum, Pt, is in valence state II and is coordinated to A in a cis configuration; A is ammonia or a monodenate alkylamine; A 2 is a bidentate alkylamine; and C 3 H 5 O 3 is the lactate anion.
Claim 2
Dependent Claim
53 words
A complex of the general formula: cis-[Pt(II)A.sub.2 (C.sub.3 H.sub.5 O.sub.3).sub.2 ] wherein the platinum, Pt, is in valence state II and is coordinated to A in a cis configuration; A is ammonia or a monodenate alkylamine; A 2 is a bidentate alkylamine; and C 3 H 5 O 3 is the lactate anion.
Claim 3
Dependent Claim
22 words
A complex according to claim 15 wherein A is represented by formula RNH 2 , and R is hydrogen or lower alkyl.
Claim 4
Dependent Claim
10 words
A complex according to claim 2 wherein R is hydrogen.
Claim 5
Dependent Claim
12 words
A complex according to claim 2 wherein R is a lower alkyl.
Claim 6
Dependent Claim
10 words
A complex according to claim 4 wherein R is methyl.
Claim 7
Dependent Claim
27 words
A complex according to claim 4 wherein A is represented by the formula: ##STR4## wherein each of R 1 and R 2 is hydrogen or lower alkyl.
Claim 8
Dependent Claim
16 words
A complex according to claim 6 wherein each of R 1 and R 2 is hydrogen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-06-01 | 1984-12-01 | 1985-06-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-06-01 | 1988-12-01 | 1989-06-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-06-01 | 1992-12-01 | 1993-06-02 | $7700.00 | Window Closed / Lapsed |