Abstract Novel compounds of the formula ##STR1## wherein A is methylene, ethylene or ethylidene; R 1 is --C.tbd.CH or --CH═CH 2 ; R 2 is hydrogen or COR wherein R is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR 4 R 5 wherein each of R 4 and R 5 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms or ##STR2## wherein R 6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R a is hydrogen, ##STR3## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR4## wherein R 7 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; and R b has the same meaning as defined for R a except R b is not ##STR5## and R a and R b can be the same or different; with the provisos that when R 2 is hydrogen, R 1 is --C.tbd.H; when A is ethylidene, R 2 is hydrogen; and when R a is ##STR6## A is methylene; and pharmaceutically acceptable salts and individual optical isomers thereof.
A compound of the formula ##STR35## wherein A is methylene, ethylene or ethylidene; R 1 is --C.tbd.CH; R 2 is hydrogen; R a is hydrogen, ##STR36## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR37## wherein R 7 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl, or p-hydroxybenzyl; R b has the same meaning as defined for R a except R b is not ##STR38## and R a and R b can be the same or different; with the proviso that when R a is ##STR39## A is methylene; and pharmaceutically acceptable salts and individual isomers thereof.
Claim 2
Dependent Claim
133 words
A compound of the formula ##STR35## wherein A is methylene, ethylene or ethylidene; R 1 is --C.tbd.CH; R 2 is hydrogen; R a is hydrogen, ##STR36## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR37## wherein R 7 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl, or p-hydroxybenzyl; R b has the same meaning as defined for R a except R b is not ##STR38## and R a and R b can be the same or different; with the proviso that when R a is ##STR39## A is methylene; and pharmaceutically acceptable salts and individual isomers thereof.
Claim 3
Dependent Claim
13 words
A compound of claim 1 wherein R a and/or R b is hydrogen.
Claim 4
Dependent Claim
14 words
A compound of claim 1 which is 1,4-hex-2-en-5-ynediamine or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
A compound of claim 1 which is 2,5-hept-3-en-6-ynediamine or a pharmaceutically acceptable salt thereof.