US4265879A
Expired / Lapsed
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Method for controlling blood triglycerides
Assignee: Monsanto Co
•
Filing: 1979-03-29
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Granted: 1981-05-05
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Expires: 1999-03-29
Abstract
Abstract The level of blood triglycerides is controlled by administration of polymers of unsaturated carboxylic acids, for example, copolymers of such acids with high molecular weight olefins or vinyl ethers.
Inventors
- 👤 Joseph E. Fields
- 👤 John H. Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:14
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A61K31/785
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
80 words
A method for controlling the blood triglyceride level in a living animal body in need thereof comprising orally administering to said animal body a pharmaceutically effective amount for such purpose of a non-systemic copolymer of (1) an alpha alkene of about 10 to about 22 carbon atoms and (2) maleic acid or anhydride, or a pharmaceutically acceptable amide, ester, imide, salt thereof or mixtures thereof, said copolymer having a molecular weight in the range of from about 1,000 to 1,000,000.
Claim 2
Independent Claim
80 words
A method for controlling the blood triglyceride level in a living animal body in need thereof comprising orally administering to said animal body a pharmaceutically effective amount for such purpose of a non-systemic copolymer of (1) an alpha alkene of about 10 to about 22 carbon atoms and (2) maleic acid or anhydride, or a pharmaceutically acceptable amide, ester, imide, salt thereof or mixtures thereof, said copolymer having a molecular weight in the range of from about 1,000 to 1,000,000.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the copolymer is octadecene-1/maleic anhydride.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the copolymer is decene-1/maleic anhydride.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the copolymer is octadecene-1/maleic acid.
Claim 6
Dependent Claim
27 words
The method of claim 1 in which the copolymer is a lipophilic copolymer of an alpha-alkene of 10 to 22 carbon atoms and maleic acid or anhydride.
Claim 7
Dependent Claim
22 words
The method of claim 1 in which the copolymer is a polyelectrolyte copolymer of an alkene of 10 to 22 carbon atoms.
Claim 8
Dependent Claim
15 words
The method of claim 1 in which the alkene has 10 to 18 carbon atoms.
Claim 9
Dependent Claim
21 words
The method of claim 1 in which the maleic component of the copolymer is a mixture of the recited maleic components.
Claim 10
Dependent Claim
17 words
The method of claim 1 in which the copolymer is a copolymer of maleic acid or anhydride.
Claim 11
Dependent Claim
18 words
The method of claim 1 further defined in that the control is achieved by interfering with fat absorption.
Claim 12
Dependent Claim
19 words
The method of claim 1 in which non-fasting triglyceride levels in the animal body are in need of control.
Claim 13
Dependent Claim
19 words
The method of claim 1 in which fasting triglyceride levels in the animal body are in need of control.
Claim 14
Dependent Claim
22 words
The method of claim 1 in which a low fat diet is used for control along with oral administration of said copolymer.
Claim 15
Dependent Claim
15 words
The method of claim 1 in which the animal body is on an atherogenic diet.
Claim 16
Dependent Claim
22 words
The method of claim 1 in which the triglycerides are controlled to values near that obtainable by a normal low fat diet.
Claim 17
Dependent Claim
18 words
The method of claim 1 in which the living animal body does not have an elevated cholesterol level.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-04 | 1984-11-03 | 1985-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-04 | 1988-11-03 | 1989-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-04 | 1992-11-03 | 1993-05-05 | $7700.00 | Window Closed / Lapsed |