US4264577A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Contraceptive methods and compositions
Assignee: Eli Lilly and Co
•
Filing: 1980-04-08
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Granted: 1981-04-28
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Expires: 2000-04-08
Abstract
Abstract Introduction of a compound of the formula: R--OSO.sub.3 --M wherein R is: (a) C 11 -C 30 straight chain alkyl or alkenyl; (b) C 10 -C 30 branched chain alkyl or alkenyl, the α-carbon of which is not branched; or (c) C 13 -C 30 branched chain alkyl or alkenyl, the α-carbon of which is branched, and M is a pharmaceutically acceptable non-toxic cation; into the uterine lumen or vaginal cavity prevents conception. Sodium n-tetradecyl sulfate is preferred.
Inventors
- 👤 Ronald E. Zimmerman
- 👤 Philip J. Burck
- 👤 C. David Jones
- 👤 Arvind L. Thakkar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/255; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0039
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
129 words
A contraceptive composition suitable for insertion and comfortable retention in the uterine lumen which comprises: (a) about 1 to about 40 percent by weight of a compound of the formula: R--OSO.sub.3 --M wherein R is: (a) C 11 -C 30 straight chain alkyl or alkenyl; (b) C 10 -C 30 branched chain alkyl or alkenyl, the α-carbon of which is not branched; or (c) C 13 -C 30 branched chain alkyl or alkenyl, the α-carbon of which is branched; and M is a pharmaceutically acceptable non-toxic cation; and (b) about 60 to about 99 percent by weight of a biocompatible, bioinsoluble, flexible silicone rubber carrier matrix, said matrix being capable of continuously releasing said compound into the uterine fluids at a controlled rate over a prolonged period of time.
Claim 2
Dependent Claim
129 words
A contraceptive composition suitable for insertion and comfortable retention in the uterine lumen which comprises: (a) about 1 to about 40 percent by weight of a compound of the formula: R--OSO.sub.3 --M wherein R is: (a) C 11 -C 30 straight chain alkyl or alkenyl; (b) C 10 -C 30 branched chain alkyl or alkenyl, the α-carbon of which is not branched; or (c) C 13 -C 30 branched chain alkyl or alkenyl, the α-carbon of which is branched; and M is a pharmaceutically acceptable non-toxic cation; and (b) about 60 to about 99 percent by weight of a biocompatible, bioinsoluble, flexible silicone rubber carrier matrix, said matrix being capable of continuously releasing said compound into the uterine fluids at a controlled rate over a prolonged period of time.
Claim 3
Dependent Claim
13 words
A composition as defined in claim 1 wherein the silicone rubber is dimethylpolysiloxane.
Claim 4
Dependent Claim
19 words
A composition as defined in claim 1 or 2, wherein R is C 11 -C 20 straight chain alkyl.
Claim 5
Dependent Claim
11 words
A composition as defined in claim 3 wherein M is sodium.
Claim 6
Dependent Claim
11 words
A composition as defined in claim 3 wherein R is n-tetradecyl.
Claim 7
Dependent Claim
11 words
A composition as defined in claim 5 wherein M is sodium.
Claim 8
Dependent Claim
32 words
A composition as defined in claim 1 or 2 wherein R is 2-tetradecyl, 4-tetradecyl, 6-tetradecyl, 7-tetradecyl, 7-hexadecyl, 8-hexadecyl, 9-octadecyl, 12-methyltridecyl, tetrahydrogeranyl, 3, 7, 11-trimethyldodecyl, 2-octyldecyl, myristoleyl, myristeladyl, oleyl, eladyl, linoleyl, or 13-methyltridec-9-enyl.
Claim 9
Dependent Claim
11 words
A composition as defined in claim 7 wherein M is sodium.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-27 | 1984-10-27 | 1985-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-27 | 1988-10-27 | 1989-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-27 | 1992-10-27 | 1993-04-28 | $7700.00 | Window Closed / Lapsed |