US3888975A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Erodible intrauterine device
Assignee: Alza Corp
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Filing: 1972-12-27
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Granted: 1975-06-10
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Expires: 1992-12-27
Abstract
Abstract An intrauterine device for administering drug locally to the uterus at a controlled rate for a prolonged period of time is disclosed. The device contains a body of polymer capable of bioeroding in the environment of the uterus over a prolonged period of time. This body has the drug dispersed throughout so that as the body gradually bioerodes, it slowly releases the dispersed drug. In a preferred embodiment, the device releases a uterine contraction-inducing prostaglandin locally to the uterus at a controlled rate over a prolonged period of time.
Inventors
- 👤 Peter W Ramwell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0039; A61F; A61F6/00; A61F6/06; A61F6/14; A61F6/142; A61F6/144; A61K31/00; A61K31/557; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
162 words
AN INTRAUTERINE DEVICE FOR THE CONTROLLED LOCAL ADMINISTRATION OF PROSTAGLANDIN TO THE UTERUS COMPRISING A HOLLOW CERVICAL CYLINDRICAL BODY HAVING A CENTRAL PASSEGWAY SHAPED AND SIZED FOR INSERTION AND RETENTION IN THE UTERUS, THE BODY MADE OF A RELEASE RATE CONTROLLING MATERIAL CONSISTING ESSENTIALLY OF CROSS-LINKED GELATIN THAT IS CROSS-LINKED WITH A MEMBER SELECTED FROM THE GROUP CONSISTING OF AN ALDEHYDE, KETONE, CARBONDIMIDE AND DICARBOXYLIC ACID AT A CONCENTRATION OF 0.01 TO 60% BY WEIGHT OF GELATIN AT A TEMPERATURE OF 4*C TO 35*C FOR A REACTION PERIOD OF 0.1 HOUR TO 5 DAYS, THE MATERIAL CONTAINING FROM ABOUT 250 MICROGRAMS TO ABOUT 100 MILLIGRAMS OF A PROSTAGLANDIN THAT INDUCES UTERINE CONTRACTIONS, THE RELEASE RATE CONTROLLING MATERIAL BIOERODING AT A CONTROLLED RATE OVER A PERIOD OF 3 HOURS TO 30 DAYS IN RESONSE TO THE ENVIRONMENT OF THE UTERUS AND CONCURRENTLY THEREWITH RELEASING 1 MICROGRAM TO 25 MICROGRAMS PER HOUR OF THE DISPERSED PROSTAGLANDIN TO THE UTERUS TO PRODUCE THE DESIRED RESULT.
Claim 2
Dependent Claim
162 words
AN INTRAUTERINE DEVICE FOR THE CONTROLLED LOCAL ADMINISTRATION OF PROSTAGLANDIN TO THE UTERUS COMPRISING A HOLLOW CERVICAL CYLINDRICAL BODY HAVING A CENTRAL PASSEGWAY SHAPED AND SIZED FOR INSERTION AND RETENTION IN THE UTERUS, THE BODY MADE OF A RELEASE RATE CONTROLLING MATERIAL CONSISTING ESSENTIALLY OF CROSS-LINKED GELATIN THAT IS CROSS-LINKED WITH A MEMBER SELECTED FROM THE GROUP CONSISTING OF AN ALDEHYDE, KETONE, CARBONDIMIDE AND DICARBOXYLIC ACID AT A CONCENTRATION OF 0.01 TO 60% BY WEIGHT OF GELATIN AT A TEMPERATURE OF 4*C TO 35*C FOR A REACTION PERIOD OF 0.1 HOUR TO 5 DAYS, THE MATERIAL CONTAINING FROM ABOUT 250 MICROGRAMS TO ABOUT 100 MILLIGRAMS OF A PROSTAGLANDIN THAT INDUCES UTERINE CONTRACTIONS, THE RELEASE RATE CONTROLLING MATERIAL BIOERODING AT A CONTROLLED RATE OVER A PERIOD OF 3 HOURS TO 30 DAYS IN RESONSE TO THE ENVIRONMENT OF THE UTERUS AND CONCURRENTLY THEREWITH RELEASING 1 MICROGRAM TO 25 MICROGRAMS PER HOUR OF THE DISPERSED PROSTAGLANDIN TO THE UTERUS TO PRODUCE THE DESIRED RESULT.
Claim 3
Dependent Claim
39 words
The device in accordance with claim 1 wherein the prostaglandin is selected from the group consisting of 11 Alpha , 15(S)-dihydroxy-9-oxo-13-trans-prostenoic acid; 11 Alpha ,15(S)-dihydroxy-9-oxo-5-cis-13trans-prostadienoic acid; 9 Alpha ,11 Alpha ,15(S)-trihydroxy-5-cis-13-trans-prostatrienoic acid; and methyl 9 Alpha ,11 Alpha ,15(S)-trihydroxy-5-cis-13-trans-prostatrienoate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-09 | 1978-12-09 | 1979-06-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-09 | 1982-12-09 | 1983-06-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-09 | 1986-12-09 | 1987-06-10 | $7700.00 | Window Closed / Lapsed |