US4264576A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Contraceptive methods and compositions
Assignee: Eli Lilly and Co
•
Filing: 1980-04-08
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Granted: 1981-04-28
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Expires: 2000-04-08
Abstract
Abstract Introduction of a pharmaceutically acceptable non-toxic cation salt of a sulfoalkyl alkanoate, for example, sodium sulfopropyl dodecanoate, into the uterine lumen or vaginal cavity prevents conception.
Inventors
- 👤 Ronald E. Zimmerman
- 👤 Philip J. Burck
- 👤 C. David Jones
- 👤 Arvind L. Thakkar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A61K9/0039
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
128 words
A contraceptive composition suitable for insertion and comfortable retention in the uterine lumen which comprises: (a) about 1 to about 40 percent by weight of a sulfoalkyl alkanoate salt of the formula ##STR15## wherein R is a straight-chain alkyl group having from 9 to 13 carbon atoms, a branched chain alkyl group having from 9 to 17 carbon atoms, or an alkenyl group having from 9 to 13 carbon atoms; n is 2, 3 or 4; and M is a pharmaceutically acceptable, non-toxic cation and (b) about 60 to about 99 percent by weight of a biocompatible, bioinsoluble, flexible silicone rubber carrier matrix, said matrix being capable of continuously releasing said sulfoalkyl alkanoate salt into the uterine fluids at a controlled rate over a prolonged period of time.
Claim 2
Dependent Claim
128 words
A contraceptive composition suitable for insertion and comfortable retention in the uterine lumen which comprises: (a) about 1 to about 40 percent by weight of a sulfoalkyl alkanoate salt of the formula ##STR15## wherein R is a straight-chain alkyl group having from 9 to 13 carbon atoms, a branched chain alkyl group having from 9 to 17 carbon atoms, or an alkenyl group having from 9 to 13 carbon atoms; n is 2, 3 or 4; and M is a pharmaceutically acceptable, non-toxic cation and (b) about 60 to about 99 percent by weight of a biocompatible, bioinsoluble, flexible silicone rubber carrier matrix, said matrix being capable of continuously releasing said sulfoalkyl alkanoate salt into the uterine fluids at a controlled rate over a prolonged period of time.
Claim 3
Dependent Claim
13 words
A composition as defined in claim 1 wherein the silicone rubber is dimethylpolysiloxane.
Claim 4
Dependent Claim
35 words
A composition as defined in claim 1 or 2, wherein the sulfoalkyl alkanoate is: sulfopropyl n-decanoate, sulfopropyl n-dodecanoate, sulfopropyl n-tridecanoate, sulfopropyl n-tetradecanoate, sulfopropyl 15-methylheptadecanoate, sulfopropyl 16-methylheptadecanoate, sulfopropyl myristoleate, sulfopropyl myristelaidate, sulfopropyl 12-methyltridecanoate, or sulfoethyl n-dodecanoate.
Claim 5
Dependent Claim
12 words
A composition as defined in claim 3 wherein the cation is sodium.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-27 | 1984-10-27 | 1985-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-27 | 1988-10-27 | 1989-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-27 | 1992-10-27 | 1993-04-28 | $7700.00 | Window Closed / Lapsed |