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US4261990A
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N-alkyleneiminoalkyl-dicarboximides as antiallergics and antiasthmatics
Assignee: Novartis Corp
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Filing: 1979-03-09
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Granted: 1981-04-14
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Expires: 1999-03-09
Abstract
Abstract N-(diphenylmethoxy-mono- or bicyclic-alkyleneiminoalkyl)-dicarboximides, e.g. those of the formula ##STR1## A=aliphatic or cycloaliphatic radical R,R'=H, alkyl, halogen or CF 3 R"=H or both are ethylene q=2-4 and salts thereof are antiallergics and antiasthmatics.
Inventors
- 👤 Robert M. Bowman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 19:43
CPC Classifications
C; C07; C07D; C07D451/00; C07D451/02; C07D451/04; C07D451/06; C07D451/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
136 words
A compound of the formula ##STR8## wherein each of Ph and Ph' is phenyl, unsubstituted or monosubstituted by lower alkyl, halogeno or trifluoromethyl; each of R 1 and R 2 are hydrogen, alkyl with up to 3 carbon atoms, or both (R 1 +R 2 ) together represent alkylene with up to 3 carbon atoms; each of m and n is an integer from 1 to 3; p is an integer from 2 to 7, whereby C p H 2p separates the adjacent nitrogen atoms by at least 2 carbon atoms; and A is alkylene or alkenylene with 2-7 carbon atoms, 4 to 7 ring-membered mono- or bicyclo-alkylene or -alkenylene, or 4 to 7 ring-membered 2-spiro-cycloalkane- (ethylene or 1,3-propylene) unsubstituted or ring-substituted by up to three lower alkyls, or a therapeutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
136 words
A compound of the formula ##STR8## wherein each of Ph and Ph' is phenyl, unsubstituted or monosubstituted by lower alkyl, halogeno or trifluoromethyl; each of R 1 and R 2 are hydrogen, alkyl with up to 3 carbon atoms, or both (R 1 +R 2 ) together represent alkylene with up to 3 carbon atoms; each of m and n is an integer from 1 to 3; p is an integer from 2 to 7, whereby C p H 2p separates the adjacent nitrogen atoms by at least 2 carbon atoms; and A is alkylene or alkenylene with 2-7 carbon atoms, 4 to 7 ring-membered mono- or bicyclo-alkylene or -alkenylene, or 4 to 7 ring-membered 2-spiro-cycloalkane- (ethylene or 1,3-propylene) unsubstituted or ring-substituted by up to three lower alkyls, or a therapeutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
126 words
A compound as claimed in claim 1, in which formula each of Ph and Ph' is phenyl, (lower alkyl)-phenyl, (halogen)-phenyl or (trifluoromethyl)-phenyl, each of R 1 and R 2 are hydrogen, alkyl with up to 3 carbon atoms, or both (R 1 +R 2 ) together represent alkylene with up to 3 carbon atoms; each of m and n is an integer from 1 to 3; p is an integer from 2 to 7, whereby C p H 2p separates the adjacent nitrogen atoms by at least 2 carbon atoms; and A is alkylene or alkenylene with 2-7 carbon atoms, 4 to 7 ring-membered mono- or bicyclic 1,2- or 1,3-cycloalkylene or -cyclo-alkenylene, or 4 to 7 ring-membered 2-spirocycloalkane-1,3-propylene, or a therapeutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
121 words
A compound as claimed in claim 1, in which formula each of Ph and Ph' is phenyl, (lower alkyl)-phenyl, (halogeno)-phenyl or (trifluoromethyl)-phenyl; each of R 1 and R 2 is hydrogen or both (R 1 +R 2 ) together are alkylene with 2 or 3 carbon atoms; each of m and n is the integer 2 or 3; p is an integer from 2 to 4, whereby C p H 2p separates the adjacent nitrogen atoms by at least 2 carbon atoms; and A is straight or branched alkylene or alkenylene with 2-7 carbon atoms, 4 to 7 ring-membered mono- or bicyclic 1,2- or 1,3-cycloalkylene or -chcloalkeneylene, or 4 to 7 ring-membered 2-spirocycloalkane-1,3-propylene, or a therapeutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
79 words
A compound as claimed in claim 1 and corresponding to the formula ##STR9## wherein each of R and R' is hydrogen, alkyl with 1-4 carbon atoms, halogeno or trifluoromethyl; each of R" is hydrogen or both R" together represent ethylene; q is 2 to 4, r is 0 or 1 and each of R"', is alkyl with 1-4 carbon atoms, or both R"' together stand for alkylene with 3-5 carbon atoms, or a therapeutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
67 words
A compound as claimed in claim 4, in which formula each of R and R' is hydrogen, methyl or chlorine, each of R" is hydrogen or both R" together are ethylene forming with the bridge heads and the nitrogen atom a 5-membered ring; q is 2 or 3 r is one and both R"' stand for 1,3-propylene or 1,4-butylene; or a therapeutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
19 words
A compound as claimed in claim 4 and being the N-[2-(4-diphenylmethoxy-piperidino)-ethyl]-β,β-tetramethylene-glutarimide, or a therapeutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
25 words
An antiallergic and antiasthmatic pharmaceutical composition consisting essentially of a correspondingly effective amount of a compound claimed in claim 1, together with a pharmaceutical excipient.
Claim 9
Dependent Claim
27 words
A method of treating allergic and asthmatic conditions in mammals, which consists in administering to said mammals enterally or parenterally a composition as claimed in claim 7.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-13 | 1984-10-13 | 1985-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-13 | 1988-10-13 | 1989-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-13 | 1992-10-13 | 1993-04-14 | $7700.00 | Window Closed / Lapsed |