US4261887A
Expired / Lapsed
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Peptide compositions
Assignee: Salk Institute for Biological Studies
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Filing: 1977-11-07
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Granted: 1981-04-14
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Expires: 1997-11-07
Abstract
Abstract Peptides have been synthesized which influence the secretion of gonadotropins by the pituitary gland of mammalians, including humans. Some of the peptides promote the release of gonadotropins, while other peptides inhibit the release.
Inventors
- 👤 Max S. Amoss
- 👤 Michael W. Monahan
- 👤 Wylie W. Vale, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:46
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/16; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
46 words
A peptide which inhibits the release of gonadotropins by the pituitary gland having the formula pGlu-R 1 -Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-X wherein R 1 is selected from Gly, Asp, Cys, D-Ala and des R 1 and wherein X is selected from Gly-NH 2 and NHCH 2 CH 3 .
Claim 2
Dependent Claim
46 words
A peptide which inhibits the release of gonadotropins by the pituitary gland having the formula pGlu-R 1 -Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-X wherein R 1 is selected from Gly, Asp, Cys, D-Ala and des R 1 and wherein X is selected from Gly-NH 2 and NHCH 2 CH 3 .
Claim 3
Dependent Claim
12 words
A peptide in accordance with claim 1 wherein R 1 is Gly.
Claim 4
Dependent Claim
12 words
A peptide in accordance with claim 1 wherein R 1 is Asp.
Claim 5
Dependent Claim
12 words
A peptide in accordance with claim 1 wherein R 1 is D-Ala.
Claim 6
Dependent Claim
15 words
A peptide in accordance with claim 1 wherein R 1 is des R 1 .
Claim 7
Dependent Claim
13 words
A peptide in accordance with claim 1 wherein X is Gly-NH 2 .
Claim 8
Dependent Claim
15 words
A peptide in accordance with claim 1 wherein X is NHCH 2 CH 3 .
Claim 9
Dependent Claim
18 words
A peptide in accordance with either claim 4 or 5 wherein X is NHCH 2 CH 3 .
Claim 10
Dependent Claim
18 words
A peptide which inhibits the release of gonadotropins by the pituitary gland having the formula pGlu-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH 2 .
Claim 11
Dependent Claim
18 words
A peptide which inhibits the release of gonadotropins by the pituitary gland having the formula pGlu-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH 2 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-13 | 1984-10-13 | 1985-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-13 | 1988-10-13 | 1989-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-13 | 1992-10-13 | 1993-04-14 | $7700.00 | Window Closed / Lapsed |