Perhalomethylcarbinol-substituted phenol and naphthol sulfamphthaleins

Claim 1

A compound of the formula ##STR62## wherein R 0 is perhalomethyl selected from trifluoromethyl, difluoromethyl, difluorochloromethyl, dichlorofluoromethyl, dichloromethyl and trichloromethyl; R 1 is selected from hydrogen and perhalomethyl having the same meaning given above; R 2 is hydrogen or methyl; R 3 is hydrogen, alkyl or alkoxy; R 2 and R 3 taken together represent the carbon atoms necessary to complete a fused benzene ring; R 4 and R 6 each are selected from hydrogen, alkyl, alkoxy, chloro and fluoro; R 7 is hydrogen, hydroxy, alkyl or alkoxy; R 6 and R 7 taken together represent the carbon atoms necessary to complete a fused benzene ring provided R 2 and R 3 are taken separately when R 6 and R 7 are taken together; R 5 is selected from hydrogen, hydroxy, alkyl, alkoxy, --N,N--(dialkyl)amino, --N,N--(ω-R 8 alkyl) 2 amino wherein R 8 is hydroxy or halo; --NHCOCH 3 , piperidino, pyrrolidino, N-methylpiperazino, morpholino, thiomorpholino or tetrahydro-2H,4H-1,3,6-dioxazocino; R 4 , R 5 and R 6 taken together represent the atoms necessary to complete a fused [ij]quinolizidine ring; Z is a group selected from ##STR63## wherein R is alkyl having 1 to 7 carbon atoms or phenyl and ##STR64## wherein Y is hydrogen or an electron-withdrawing group having a positive sigma value greater than 0.6 as defined by Hammett's Equation; and X represents the atoms necessary to complete 2,3-dihydrobenz[d]isothiazole-1,1-dioxide or 2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxide.