US4259320A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Concurrent use of avoparcin with growth-promoting implants in cattle
Assignee: DSM Nutritional Products LLC
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Filing: 1979-03-02
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Granted: 1981-03-31
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Expires: 1999-03-02
Abstract
Abstract This disclosure describes a combination treatment for ruminants to synergistically enhance the growth rate thereof and improve the efficiency of feed utilization thereby. The treatment involves, orally administering a growth-enhancing amount of the antibiotic AV290, antibiotic AV290 sulfate, antibiotic AV290-syntan complex, antibiotic AV290-alkyl sulfate complex and/or antibiotic AV290 alkylated derivative, to ruminants which have been parenterally or orally treated with a growth-enhancing amount of a selected steroid or steroidal composition.
Inventors
- 👤 Roger L. De Lay
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 03:46
CPC Classifications
A; A61; A61K; A61K35/00; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A23; A23K; A23K20/00; A23K20/10; A23K20/168; A23K20/184; A23K20/195; A61P; A61P43/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
97 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of ruminants; comprising, parenterally administering to said ruminants weighing between 180 kg and 500 kg growth-enhancing amount of a compound or composition selected from the group consisting of: (1) progesterone plus estradiol benzoate; (2) testosterone plus estradiol benzoate; and (3) 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one; and in conjunction therewith, orally administering to said ruminants, in or with their feed, a growth-enhancing amount of antibiotic selected from the group consisting of: AV290, antibiotic AV290 sulfate, antibiotic AV290-syntan complex, antibiotic AV290-alkyl sulfate, or antibiotic AV290 alkylated derivative and mixtures thereof.
Claim 2
Independent Claim
97 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of ruminants; comprising, parenterally administering to said ruminants weighing between 180 kg and 500 kg growth-enhancing amount of a compound or composition selected from the group consisting of: (1) progesterone plus estradiol benzoate; (2) testosterone plus estradiol benzoate; and (3) 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one; and in conjunction therewith, orally administering to said ruminants, in or with their feed, a growth-enhancing amount of antibiotic selected from the group consisting of: AV290, antibiotic AV290 sulfate, antibiotic AV290-syntan complex, antibiotic AV290-alkyl sulfate, or antibiotic AV290 alkylated derivative and mixtures thereof.
Claim 3
Dependent Claim
123 words
A method according to claim 1, wherein said orally administered AV290 antibiotic, AV290 sulfate, AV290-syntan complex, AV290 alkyl sulfate, AV290 alkylated derivative or mixtures thereof is administered to said ruminants in a feed containing 30 ppm to 100 ppm of said antibiotic determined on the basis of dry matter in said feed; and said parenterally administered compound or composition is administered as a subcutaneous implant under the skin of the ears of said ruminants and is selected from the group consisting of implants containing: (1) 150 mg to 250 mg progesterone plus 10 mg to 30 mg estradiol benzoate; (2) 150 mg to 250 mg testosterone plus 10 mg to 30 mg of estradiol benzoate; or, (3) 25 mg to 50 mg 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one.
Claim 4
Dependent Claim
26 words
A method according to claim 2, wherein said orally administered antibiotic is administered to ruminants at a dose level of from 150 mg to 1250 mg/head/day.
Claim 5
Independent Claim
68 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of cattle weighing between 180 kg and 500 kg; comprising, orally administering to said cattle a feed containing from 40 ppm to 75 ppm (dry weight basis) of AV290 sodium lauryl sulfate, and in conjunction therewith parenterally administering to said cattle a subcutaneous implant containing 200 mg of progesterone and 20 mg of estradiol benzoate.
Claim 6
Independent Claim
68 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of cattle weighing between 180 kg and 500 kg; comprising, orally administering to said cattle a feed containing from 40 ppm to 75 ppm (dry weight basis) of AV290 sodium lauryl sulfate, and in conjunction therewith parenterally administering to said cattle a subcutaneous implant containing 200 mg of progesterone and 20 mg of estradiol benzoate.
Claim 7
Dependent Claim
18 words
A method according to claim 4, wherein said cattle feed contains 50 ppm of AV290 sodium lauryl sulfate.
Claim 8
Independent Claim
71 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of cattle weighing between 180 kg and 500 kg; comprising, orally administering to said cattle, in or with their feed, from 250 mg to 625 mg per head per day of antibiotic AV290 sodium lauryl sulfate; and in conjunction therewith, administering to said cattle a subcutaneous implant containing 200 mg of progesterone and 20 mg of estradiol benzoate.
Claim 9
Independent Claim
71 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of cattle weighing between 180 kg and 500 kg; comprising, orally administering to said cattle, in or with their feed, from 250 mg to 625 mg per head per day of antibiotic AV290 sodium lauryl sulfate; and in conjunction therewith, administering to said cattle a subcutaneous implant containing 200 mg of progesterone and 20 mg of estradiol benzoate.
Claim 10
Independent Claim
68 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of cattle weighing between 180 kg and 500 kg; comprising, orally administering to said cattle, in or with their feed, about 350 mg per head per day of antibiotic AV290 sodium lauryl sulfate; and in conjunction therewith, administering to said cattle a subcutaneous implant containing 200 mg of progesterone and 20 mg of estradiol benzoate.
Claim 11
Independent Claim
68 words
A method for synergistically enhancing the growth rate and efficiency of feed utilization of cattle weighing between 180 kg and 500 kg; comprising, orally administering to said cattle, in or with their feed, about 350 mg per head per day of antibiotic AV290 sodium lauryl sulfate; and in conjunction therewith, administering to said cattle a subcutaneous implant containing 200 mg of progesterone and 20 mg of estradiol benzoate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-30 | 1984-09-29 | 1985-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-30 | 1988-09-29 | 1989-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-30 | 1992-09-29 | 1993-03-31 | $7700.00 | Window Closed / Lapsed |