Patent US4256751A successfully refreshed from Google Patents.
US4256751A
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Tetrahydroisoquinoline derivatives
Assignee: Tanabe Pharma Corp
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Filing: 1979-11-08
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Granted: 1981-03-17
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Expires: 1999-11-08
Abstract
Abstract A compound of the formula: <IMAGE> (I) wherein R1 is hydrogen or methyl, is prepared by condensing a compound of the formula: <IMAGE> (II) wherein R2 is alkyl, aryl or aralkyl and R1 is same as above, or a reactive derivative thereof with 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid or an ester thereof to give a compound of the formula: <IMAGE> (IV) wherein R3 is an ester residue and R1 and R2 are same as above, followed by hydrolysis or ammonolysis of said compound (IV). The compound (I) is useful as a diagnostic or therapeutic agent for angiotensin-related hypertension.
Inventors
- 👤 Kimiaki Hayashi
- 👤 Jyoji Kato
- 👤 Tomofumi Uchida
- 👤 Naoto Yoneda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:55
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/22; C07D217/26; A; A61; A61P; A61P43/00; A61P7/00; A61P7/02; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
19 words
A compound of the formula: ##STR9## wherein R 1 is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
19 words
A compound of the formula: ##STR9## wherein R 1 is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1, in which R 1 is methyl.
Claim 4
Dependent Claim
15 words
The compound of claim 1, which is (3S)-2-[(2S)-3-mercapto-2-methylpropionyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
54 words
A hypotensive composition which comprises an amount of a compound of the formula: ##STR10## wherein R 1 is hydrogen or methyl, or a pharmaceutically acceptable salt thereof, and which amount is sufficient, when administered to a warm blooded animal, to provide an effective amount thereof in said animal, and a pharmaceutically acceptable carrier therefor.
Claim 6
Dependent Claim
54 words
A hypotensive composition which comprises an amount of a compound of the formula: ##STR10## wherein R 1 is hydrogen or methyl, or a pharmaceutically acceptable salt thereof, and which amount is sufficient, when administered to a warm blooded animal, to provide an effective amount thereof in said animal, and a pharmaceutically acceptable carrier therefor.
References Cited (Backward Citations)
CA633216A
Cited
US4046889A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-16 | 1984-09-15 | 1985-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-16 | 1988-09-15 | 1989-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-16 | 1992-09-15 | 1993-03-17 | $7700.00 | Window Closed / Lapsed |