Fluorine-containing 1,4-dihydropyridine compounds, pharmaceutical compositions thereof and their medicinal use

Claim 1

A fluorine-containing 1,4-dihydropyridine of the formula ##STR58## or a salt thereof, in which R denotes a hydrogen atom an alkyl group having up to 8 carbon atoms or an aralkyl group which is monocyclic or bicyclic carbocyclic in the aryl portion and contains up to 8 carbon atoms in the alkyl portion, R 1 and R 6 identical or different and each denotes an alkyl group having up to 8 carbon atoms, R 4 represents alkyl having up to 8 carbon atoms or represents a monocyclic or bicyclic carbocyclic aryl radical which is optionally substituted by 1 or 2 identical or different substituents selected from nitro, cyano, trifluoromethyl, halogen, azido, trifluoromethoxy, alkyl, alkoxy, alkylmercapto and SO 2 --alkyl, each of said alkyl, alkoxy, alkylmercapto and SO 2 --alkyl groups having up to 8 carbon atoms, or denotes a quinolyl, pyridyl, pyrimidyl, thienyl or furyl radical which is optionally substituted by alkyl having up to 8 carbon atoms or halogen, R 5 denotes an alkyl group having up to 8 carbon atoms which is optionally substituted by halogen, or denotes an alkenyl, alkynyl, alkoxyalkyl or aminoalkyl group, each having up to 8 carbon atoms, it being possible for the two hydrogen atoms of the amino group to be replaced by 1 or 2 alkyl groups each having up to 8 carbon atoms and/or by an aralkyl group as defined above for R, or denotes a radical of the formula ##STR59## and R 2 and R 3 in each case are identical or different and either one of the two substituents denotes a hydrogen atom and the other substituent denotes, or each of the two substituents denotes, a straight-chain, branched or cyclic radical group having up to 8 carbon atoms or an aralkyl group which is monocyclic or bicyclic carbocyclic in the aryl portion and contains up to 8 carbon atoms in the alkyl portion which contains at least 1 perfluorinated carbon atom having 2 or 3 fluorine substituents, this alkyl radical optionally being interrupted by the group --CH 2 --X--CH 2 --, in which X denotes oxygen or sulphur, or in which R 2 and R 3 together with the CH group complete a saturated isocyclic ring which has 4 to 7 ring members and contains at least 1 perfluorinated carbon atom and is optionally substituted by an alkyl group, it being possible for this alkyl group, in turn, again to contain 1 or 2 perfluorinated carbon atoms. in which X denotes oxygen or sulphur, or in which R 2 and R 3 together with the CH group completes a saturated isocyclic radical which has 4 to 7 ring members and contains 1, 2 or 3 perfluorinated carbon atoms and is optionally substituted by an alkyl group with 1 to 4 carbon atoms, it being possible for this alkyl group, in turn, again to contain one or two perfluorinated carbon atoms.