US4256743A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibition of bone resorption with H1 -blocking antihistamines
Assignee: Harvard University
•
Filing: 1979-10-26
•
Granted: 1981-03-17
•
Expires: 1999-10-26
Abstract
Abstract Inhibition of bone resorption in mammals suffering from a disease in which bone resorption exceeds new bone formation by administering an H1-blocking antihistamine.
Inventors
- 👤 Paul Goldhaber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/54
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
88 words
A method for inhibiting bone resorption which comprises administering orally to a mammal suffering from osteoporosis or chronic destructive periodontal disease an H 1 -blocking antihistamine selected from the group consisting of the H 1 -blocking phenothiazines, the H 1 -blocking ethylenediamines, and the H 1 -blocking indenes, the amount being from 25-50 mg/day in the case of said phenothiazines, 25-50 mg up to 4 times a day in the case of said ethylenediamines, 1-2 mg 1 to 3 times a day in the case of said indenes.
Claim 2
Independent Claim
88 words
A method for inhibiting bone resorption which comprises administering orally to a mammal suffering from osteoporosis or chronic destructive periodontal disease an H 1 -blocking antihistamine selected from the group consisting of the H 1 -blocking phenothiazines, the H 1 -blocking ethylenediamines, and the H 1 -blocking indenes, the amount being from 25-50 mg/day in the case of said phenothiazines, 25-50 mg up to 4 times a day in the case of said ethylenediamines, 1-2 mg 1 to 3 times a day in the case of said indenes.
Claim 3
Dependent Claim
43 words
The method as claimed in claim 1 in which said H 1 -blocking phenothiazine is promethazine hydrochloride, said H 1 -blocking ethylenediamine is selected from the group consisting of tripelennamine hydrochloride and pyrilamine maleate, and said H 1 -blocking indene is dimethindene maleate.
Claim 4
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is osteoporosis and said antihistamine is promethazine hydrochloride.
Claim 5
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is osteoporosis and said antihistamine is tripellenamine hydrochloride.
Claim 6
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is osteoporosis and said antihistamine is pyrilamine maleate.
Claim 7
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is osteoporosis and said antihistamine is dimethindene maleate.
Claim 8
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is periodontitis and said antihistamine is promethazine hydrochloride.
Claim 9
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is periodontitis and said antihistamine is tripellenamine hydrochloride.
Claim 10
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is periodontitis and said antihistamine is pyrilamine maleate.
Claim 11
Dependent Claim
19 words
The method as claimed in claim 2 in which said disease is periodontitis and said antihistamine is dimethindene maleate.
Claim 12
Dependent Claim
20 words
The method as claimed in claim 1 in which said H 1 -blocking antihistamine is an H 1 -blocking phenothiazine.
Claim 13
Dependent Claim
20 words
The method as claimed in claim 1 in which said H 1 -blocking antihistamine is an H 1 -blocking ethylenediamine.
Claim 14
Dependent Claim
20 words
The method as claimed in claim 1 in which said H 1 -blocking antihistamine is an H 1 -blocking indene.
References Cited (Backward Citations)
US3070503A
Cited
US3637660A
Cited
US3726976A
Cited
US3894151A
Cited
US3920822A
Cited
US3975530A
Cited
US3932644A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-16 | 1984-09-15 | 1985-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-16 | 1988-09-15 | 1989-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-16 | 1992-09-15 | 1993-03-17 | $7700.00 | Window Closed / Lapsed |