US4256726A
Expired / Lapsed
US
⏱️ 0.0 years remaining
99m Tc-Labeled radioactive diagnostic agent, and non-radioactive carrier therefor
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1978-05-01
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Granted: 1981-03-17
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Expires: 1998-05-01
Abstract
Abstract A 99mTc-labeled radioactive diagnostic agent, prepared by contacting 99mTc in the form of a pertechnetate with a non-radioactive carrier comprising pyridoxal or salt thereof, a stannous salt and an alpha -amino acid not having any hydrophilic functional group dissolved in an aqueous medium. This diagnostic agent is suitable for the examination of hepatobiliary ducts due to its smooth transfer through the hepatobiliary ducts as well as its high stability and non-toxicity.
Inventors
- 👤 Makoto Kato
- 👤 Masaaki Hazue
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:13
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0404; A61K51/0406; A61K51/041; A61K51/044; A61K51/0455; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
27 words
A non-radioactive carrier comprising pyridoxal or a salt thereof, a stannous salt and an α-amino acid not having any hydrophilic functional group dissolved in an aqueous medium.
Claim 2
Dependent Claim
27 words
A non-radioactive carrier comprising pyridoxal or a salt thereof, a stannous salt and an α-amino acid not having any hydrophilic functional group dissolved in an aqueous medium.
Claim 3
Dependent Claim
21 words
The non-radioactive carrier according to claim 1, wherein the concentration of pyridoxal or its salt is not less than 20 mmol/liter.
Claim 4
Dependent Claim
25 words
The non-radioactive carrier according to claim 1, wherein the molar ratio of pyridoxal or its salt and the α-amino acid is from 0.3 to 3.
Claim 5
Dependent Claim
29 words
The non-radioactive carrier according to claim 1, wherein the stannous salt is used in an amount of 0.001 to 1 mol per 1 mol of pyridoxal or its salt.
Claim 6
Dependent Claim
44 words
A 99m Tc-labeled radioactive diagnostic agent which comprises 99m Tc in the form of a pertechnetate and a non-radioactive carrier comprising pyridoxal or a salt thereof, a stannous salt and an α-amino acid not having any hydrophilic functional group dissolved in an aqueous medium.
Claim 7
Dependent Claim
44 words
A 99m Tc-labeled radioactive diagnostic agent which comprises 99m Tc in the form of a pertechnetate and a non-radioactive carrier comprising pyridoxal or a salt thereof, a stannous salt and an α-amino acid not having any hydrophilic functional group dissolved in an aqueous medium.
Claim 8
Dependent Claim
78 words
The 99m Tc-labeled radioactive diagnostic agent according to claim 5, prepared by contacting an aqueous solution containing 99m Tc, the radioactivity of which is 0.1 to 50 mCi in a volume of 0.5 to 5 ml of aqueous solution at the time of administration, in the form of a pertechnetate with a non-radioactive carrier comprising pyridoxal or a salt thereof, a stannous salt and an α-amino acid not having any hydrophilic functional group dissolved in an aqueous medium.
References Cited (Backward Citations)
US3981980A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-16 | 1984-09-15 | 1985-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-16 | 1988-09-15 | 1989-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-16 | 1992-09-15 | 1993-03-17 | $7700.00 | Window Closed / Lapsed |