US3981980A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiopharmaceuticals for cholescintigraphy
Assignee: Adelaide (Anti-Cancer Foundation), University of
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Filing: 1974-08-08
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Granted: 1976-09-21
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Expires: 1994-08-08
Abstract
Abstract A diagnostic substance for cholescintigraphy which is formed by the reaction of pyridoxal and amino acids labelled with a radionuclide, in pyrogen-free water, the reaction product being adjusted to a pH of 8 to 9 and then autoclaved and cooled to produce a sterile, pyrogen-free non-antigenic solution for injection for biliary scanning.
Inventors
- 👤 Richmond J. Baker
- 👤 Johan C. Bellen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 22:51
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0497; A61K51/041; A61K51/044; A61K51/0455; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
17 words
A radiopharmaceutical for cholescintigraphy formed by the reaction of pyridoxal and amino acids labelled with a radionuclide.
Claim 2
Dependent Claim
17 words
A radiopharmaceutical for cholescintigraphy formed by the reaction of pyridoxal and amino acids labelled with a radionuclide.
Claim 3
Dependent Claim
13 words
A pharmaceutical according to claim 1 wherein said amino acid is glutamic acid.
Claim 4
Dependent Claim
46 words
A radiopharmaceutical according to claim 1 prepared by reacting the pyridoxal and an amino acid and radionuclide in pyrogen-free water, then adjusting the pH to 8-9 and displacing air therefrom with nitrogen and autoclaving and cooling whereby to produce a sterile, pyrogen-free non-antigenic solution for injection.
Claim 5
Dependent Claim
11 words
A pharmaceutical according to claim 1 wherein the radionuclide is technetium-99m.
Claim 6
Dependent Claim
60 words
A radiopharmaceutical according to claim 1 prepared by dissolving pyridoxal hydrochloride and monosodium L-glutamate monohydrate in pyrogen-free water with the addition of 99m Tc-pertechnetate, adjusting the pH to 8-9, transferring the mixture to a closed vial and displacing the air with nitrogen, autoclaving the contents of the vial, and cooling, whereby to obtain a sterile, pyrogen-free non-antigenic solution for injection.
Claim 7
Dependent Claim
40 words
A radiopharmaceutical according to claim 5 wherein the proportions used are approximately 50mg pyridoxal hydrochloride, 50mg monosodium L-glutamate monohydrate, dissolved in 2ml pyrogen-free water, 20-25 mCi 99m Tc-pertechnetate, and the reaction product is autoclaved at about 120°C for 1 hour.
Claim 8
Dependent Claim
15 words
A pharmaceutical according to claim 5 wherein the pH is adjusted by adding sodium hydroxide.
Claim 9
Dependent Claim
16 words
A pharmaceutical wherein the product of claim 1 is freeze-dried and subsequently labeled with the radionuclide.
Claim 10
Dependent Claim
22 words
A process for cholescinigraphy comprising intravenously introducing the product of claim 1 into a patient's system and monitoring the system by scintiscanning.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-21 | 1980-03-22 | 1980-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-21 | 1984-03-22 | 1984-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-21 | 1988-03-22 | 1988-09-21 | $7700.00 | Window Closed / Lapsed |