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US4255405A
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Naphthoquinone anti-psoriatic agents
Assignee: Syntex USA LLC
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Filing: 1979-05-29
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Granted: 1981-03-10
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Expires: 1999-05-29
Abstract
Abstract The 2,3-diesters of 6-substituted-2,3-dihydroxy-1,4-naphthoquinones exhibit useful anti-psoriatic activity in mammals.
Inventors
- 👤 Gordon H. Jones
- 👤 John Young
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 09:46
CPC Classifications
C; C07; C07C; C07C50/00; C07C50/26; C07C50/32; C07C17/00; C07C17/093; C07C17/10; C07C17/14; C07C45/00; C07C45/51; C07C45/54; C07C46/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
70 words
A pharmaceutical composition for relieving a condition of psoriasis in a mammal in a form suitable for topical administration to said mammal which comprises at least one pharmaceutically acceptable, non-toxic excipient and a psoriasis-relieving amount of a compound selected from those represented by the formula ##STR4## wherein R is hydrogen, halo, cyano or C 1 to C 18 alkoxy and R 1 is alkyl of one to five carbon atoms.
Claim 2
Dependent Claim
70 words
A pharmaceutical composition for relieving a condition of psoriasis in a mammal in a form suitable for topical administration to said mammal which comprises at least one pharmaceutically acceptable, non-toxic excipient and a psoriasis-relieving amount of a compound selected from those represented by the formula ##STR4## wherein R is hydrogen, halo, cyano or C 1 to C 18 alkoxy and R 1 is alkyl of one to five carbon atoms.
Claim 3
Dependent Claim
16 words
The composition of claim 1 wherein R 1 is alkyl of one or two carbon atoms.
Claim 4
Dependent Claim
11 words
The composition of claim 1 or 2 wherein R is halo.
Claim 5
Dependent Claim
20 words
The composition of claim 1 wherein R is chloro and R 1 is alkyl of one or two carbon atoms.
Claim 6
Dependent Claim
12 words
The composition of claim 4 wherein R 1 is methyl, namely 2,3-diacetoxy-6-chloro-1,4-naphthoquinone.
Claim 7
Independent Claim
57 words
A method for relieving the condition of psoriasis in a mammal which comprises topically administering to said mammal a therapeutically effective amount of a compound selected from those represented by the formula ##STR5## wherein R is hydrogen, halo, cyano or C 1 to C 18 alkoxy and R 1 is alkyl of one to five carbon atoms.
Claim 8
Independent Claim
57 words
A method for relieving the condition of psoriasis in a mammal which comprises topically administering to said mammal a therapeutically effective amount of a compound selected from those represented by the formula ##STR5## wherein R is hydrogen, halo, cyano or C 1 to C 18 alkoxy and R 1 is alkyl of one to five carbon atoms.
Claim 9
Dependent Claim
16 words
The method of claim 6 wherein R 1 is alkyl of one or two carbon atoms.
Claim 10
Dependent Claim
9 words
The method of claim 6 wherein R is halo.
Claim 11
Dependent Claim
20 words
The method of claim 6 wherein R is chloro and R 1 is alkyl of one or two carbon atoms.
Claim 12
Dependent Claim
12 words
The method of claim 9 wherein R 1 is methyl, namely 2,3-diacetoxy-6-chloro-1,4-naphthoquinone.
References Cited (Backward Citations)
US3914264A
Cited
US4115584A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-09 | 1984-09-08 | 1985-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-09 | 1988-09-08 | 1989-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-09 | 1992-09-08 | 1993-03-10 | $7700.00 | Window Closed / Lapsed |