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US4254267A
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Mercaptoacyldihydropyrazole carboxylic acid derivatives
Assignee: ER Squibb and Sons LLC
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Filing: 1979-10-25
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Granted: 1981-03-03
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Expires: 1999-10-25
Abstract
Abstract Hypotensive activity is exhibited by compounds having the formula ##STR1## wherein: R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R 5 is alkyl or aryl; R 2 is hydrogen, alkyl, or haloalkyl; R 3 is furanyl, thienyl or pyridyl; R 4 is hydrogen, alkyl or arylalkyl; and n is 0, 1 or 2.
Inventors
- 👤 George C. Rovnyak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 21:34
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07C; C07C323/00; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/55; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/54; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/24; C07D401/12; C07D405/00; C07D405/02; C07D405/04; C07D409/00; C07D409/02; C07D409/04; C07D409/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
139 words
A compound having the formula ##STR21## or a basic salt thereof, wherein: R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR22## wherein R 5 is alkyl or aryl; R 2 is hydrogen, alkyl or haloalkyl; R 3 is 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl or any of the aforementioned groups substituted with one or two halogens or alkyl groups; R 4 is hydrogen, alkyl or arylalkyl; and n is 0, 1 or 2; wherein the term "aryl", as used by itself or as part of a larger group, refers to phenyl or phenyl substituted with one, two or three halogen, alkyl, alkoxy, hydroxy, ##STR23## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups, and the terms "alkyl" and "alkoxy", as used individually or as part of a larger group, refer to groups having 1 to 8 carbon atoms.
Claim 2
Dependent Claim
139 words
A compound having the formula ##STR21## or a basic salt thereof, wherein: R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR22## wherein R 5 is alkyl or aryl; R 2 is hydrogen, alkyl or haloalkyl; R 3 is 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl or any of the aforementioned groups substituted with one or two halogens or alkyl groups; R 4 is hydrogen, alkyl or arylalkyl; and n is 0, 1 or 2; wherein the term "aryl", as used by itself or as part of a larger group, refers to phenyl or phenyl substituted with one, two or three halogen, alkyl, alkoxy, hydroxy, ##STR23## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups, and the terms "alkyl" and "alkoxy", as used individually or as part of a larger group, refer to groups having 1 to 8 carbon atoms.
Claim 3
Dependent Claim
24 words
A compound in accordance with claim 1 wherein R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR24## wherein R 5 is alkyl or aryl.
Claim 4
Dependent Claim
15 words
A compound in accordance with claim 2 wherein R 2 is hydrogen, methyl or trifluoromethyl.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is hydrogen.
Claim 6
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 7
Dependent Claim
14 words
A compound in accordance with claim 1 wherein R 3 is 2-furanyl or 2-thienyl.
Claim 8
Dependent Claim
9 words
The compound in accordance with claim 1, (±)-3-(2-furanyl)-4,5-dihydro-1-(3-mercapto-1-oxopropyl)-1H-pyrazole-5-carboxylic acid.
Claim 9
Dependent Claim
9 words
The compound in accordance with claim 1, (±)-4,5-dihydro-1-(3-mercapto-1-oxopropyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-02 | 1984-09-01 | 1985-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-02 | 1988-09-01 | 1989-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-02 | 1992-09-01 | 1993-03-03 | $7700.00 | Window Closed / Lapsed |