Patent US4252898A successfully refreshed from Google Patents.
US4252898A
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Antibiotics A6888C and A6888X
Assignee: Eli Lilly and Co
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Filing: 1979-05-23
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Granted: 1981-02-24
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Expires: 1999-05-23
Abstract
Abstract Antibiotic compounds of the formula: ##STR1## wherein R' is ##STR2## or --CH 2 OH, and the non-toxic pharmaceutically acceptable acid addition salts thereof, are produced by culturing Streptomyces flocculus NRRL 11459. Techniques for isolating the compounds are also described. Cirramycin A 1 and cirramycin B are coproduced.
Inventors
- 👤 Stephen M. Nash
- 👤 Kay F. Koch
- 👤 Marvin M. Hoehn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:11
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/60; C12P19/62; C12R; C12R2001/00; C12R2001/01; C12R2001/465; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
70 words
A method for producing cirramycin A 1 , cirramycin B, or a compound of the formula: ##STR7## wherein: (a) R' is ##STR8## and (b) R' is --CH 2 OH; or a non-toxic, pharmaceutically acceptable acid addition salt thereof comprising cultivating Streptomyces flocculus NRRL 11459 in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salt under submerged aerobic conditions until a substantial amount of each compound is produced.
Claim 2
Independent Claim
70 words
A method for producing cirramycin A 1 , cirramycin B, or a compound of the formula: ##STR7## wherein: (a) R' is ##STR8## and (b) R' is --CH 2 OH; or a non-toxic, pharmaceutically acceptable acid addition salt thereof comprising cultivating Streptomyces flocculus NRRL 11459 in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salt under submerged aerobic conditions until a substantial amount of each compound is produced.
Claim 3
Dependent Claim
16 words
A method as defined in claim 1 for producing the compound wherein R 1 is --CH.
Claim 4
Dependent Claim
17 words
A method as defined in claim 1 for producing the compound wherein R 1 --CH 2 OH.
Claim 5
Dependent Claim
13 words
A method as defined in claim 1 for producing cirramycin A 1 .
Claim 6
Dependent Claim
11 words
A method as defined in claim 1 for producing cirramycin B.
Claim 7
Dependent Claim
20 words
A method as defined in claim 2, 3, 4 or 5 wherein the compound is isolated in substantially pure form.
References Cited (Backward Citations)
US3159540A
Cited
US3950516A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-24 | 1984-08-25 | 1985-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-24 | 1988-08-25 | 1989-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-24 | 1992-08-25 | 1993-02-24 | $7700.00 | Window Closed / Lapsed |