US4252822A
Expired / Lapsed
US
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Method for treating phenylketonuria
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1979-12-26
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Granted: 1981-02-24
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Expires: 1999-12-26
Abstract
Abstract A method for improving motor and cognitive functions in mammalian subjects affected with phenylketonuria by administering a mixture of valine, isoleucine and leucine as a supplement to the restriction of phenylalanine content of their diets. The invention described herein was made in the course of work under a grant from the Department of Health, Education and Welfare.
Inventors
- 👤 Helen K. Berry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:00
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/01; A23; A23L; A23L33/00; A23L33/10; A23L33/17; A23L33/175
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
56 words
Method of improving motor and cognitive functions in mammalian subjects afflicted with phenylketonuria by administering to said subjects a mixture consisting essentially of valine, isoleucine and leucine in a total effective amount of said mixture to improve motor and cognitive functions wherein each ingredient is present in an amount to improve said motor and cognitive functions.
Claim 2
Dependent Claim
56 words
Method of improving motor and cognitive functions in mammalian subjects afflicted with phenylketonuria by administering to said subjects a mixture consisting essentially of valine, isoleucine and leucine in a total effective amount of said mixture to improve motor and cognitive functions wherein each ingredient is present in an amount to improve said motor and cognitive functions.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the afflicted subject is on a restricted phenylalanine diet.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein the mixture consists essentially of L-valine, L-isoleucine and L-leucine.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said administration is conducted orally.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein the ratio of valine, isoleucine and leucine is about 1:1:1, respectively.
Claim 7
Dependent Claim
27 words
The method of claim 1 wherein the ratio of valine, isoleucine and leucine is in a range of about 1 to about 0.5:1.5 to about 1:2, respectively.
Claim 8
Independent Claim
49 words
The method of improving motor and cognitive functions in humans afflicted with phenylketonuria by orally administering to said subjects a mixture consisting essentially of L-valine, L-isoleucine and L-leucine in a ratio of about 1:1:1, respectively, in a total effective amount of said mixture to improve motor and cognitive functions.
Claim 9
Independent Claim
49 words
The method of improving motor and cognitive functions in humans afflicted with phenylketonuria by orally administering to said subjects a mixture consisting essentially of L-valine, L-isoleucine and L-leucine in a ratio of about 1:1:1, respectively, in a total effective amount of said mixture to improve motor and cognitive functions.
Claim 10
Dependent Claim
20 words
The method of claim 7 wherein said total effective amount is in the range of about 150 to 900 mg/kg.
References Cited (Backward Citations)
US3832465A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-24 | 1984-08-25 | 1985-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-24 | 1988-08-25 | 1989-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-24 | 1992-08-25 | 1993-02-24 | $7700.00 | Window Closed / Lapsed |