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US4252793A
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Injectable lecithin preparation
Assignee: American Lecithin Co Inc
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Filing: 1979-06-18
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Granted: 1981-02-24
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Expires: 1999-06-18
Abstract
Abstract A method of preparing an injectable preparation of lecithin including 1 to 10% lecithin comprises the steps of separately preparing a lecithin fraction including lecithin and a non-hydrous liquid, separately preparing an aqueous fraction containing a surfactant, and then combining the two fractions and manually shaking for twenty to thirty seconds. Beneficial medicaments are added to either the lecithin fraction or aqueous fraction prior to combining of the two.
Inventors
- 👤 Reinout F. A. Altman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/683; A61K31/685; A61K47/00; A61K47/06; A61K47/24; A61K9/00; A61K9/0012; A61K9/0019; Y; Y10; Y10S; Y10S516/00; Y10S516/01; Y10S516/06
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
144 words
Method of providing lecithin intravenously into the human body, comprising the steps of: preparing an anhydrous mixture including approximately 10% to 80% lecithin by weight and an anhydrous liquid selected from the group consisting essentially of ethanol, monoglycerides, diglycerides, fatty acids and liquid fatty oils; preparing an aqueous mixture including water and a surfactant selected from the group consisting essentially of block polymers of ethyleneoxide and propyleneoxide, sodium cholate, dioxycholic acid and soaps; separately packaging the anhydrous mixture and the aqueous mixture; separately sterilizing the anhydrous mixture and the aqueous mixture; and combining the aqueous mixture and the anhydrous mixture prior to intravenous administration into the human body to form a non-toxic fluid preparation suitable for intravenous administration within thirty seconds after combining including 1% to 10% lecithin by weight and including particles ranging in size from less than one micron to five microns.
Claim 2
Dependent Claim
144 words
Method of providing lecithin intravenously into the human body, comprising the steps of: preparing an anhydrous mixture including approximately 10% to 80% lecithin by weight and an anhydrous liquid selected from the group consisting essentially of ethanol, monoglycerides, diglycerides, fatty acids and liquid fatty oils; preparing an aqueous mixture including water and a surfactant selected from the group consisting essentially of block polymers of ethyleneoxide and propyleneoxide, sodium cholate, dioxycholic acid and soaps; separately packaging the anhydrous mixture and the aqueous mixture; separately sterilizing the anhydrous mixture and the aqueous mixture; and combining the aqueous mixture and the anhydrous mixture prior to intravenous administration into the human body to form a non-toxic fluid preparation suitable for intravenous administration within thirty seconds after combining including 1% to 10% lecithin by weight and including particles ranging in size from less than one micron to five microns.
Claim 3
Dependent Claim
29 words
Method of claim 1, wherein the step combining the aqueous mixture and the anhydrous mixture includes the step of manually shaking the two mixtures after they have been combined.
Claim 4
Dependent Claim
26 words
Method of claim 1, further comprising the step of administering the fluid preparation intravenously into the human body immediately after forming of the non-toxic fluid preparation.
Claim 5
Independent Claim
72 words
A method of preparing lecithin for injection or infusion intravenously into the human body, said method comprising the steps of: mixing lecithin with an anhydrous liquid to form a lecithin fraction comprising 10% or more lecithin by weight; packing the lecithin fraction; sterilizing the lecithin fraction; storing the lecithin fraction and combining the lecithin fraction with an aqueous phase including water forming an injectable preparation comprising greater than 1% lecithin by weight.
Claim 6
Independent Claim
72 words
A method of preparing lecithin for injection or infusion intravenously into the human body, said method comprising the steps of: mixing lecithin with an anhydrous liquid to form a lecithin fraction comprising 10% or more lecithin by weight; packing the lecithin fraction; sterilizing the lecithin fraction; storing the lecithin fraction and combining the lecithin fraction with an aqueous phase including water forming an injectable preparation comprising greater than 1% lecithin by weight.
Claim 7
Dependent Claim
63 words
An anhydrous lecithin fraction capable of being sterilized and stored for long periods of time prior to combining with water for human injection, said lecithin fraction comprising an anhydrous liquid selected from the group consisting essentially of ethanol, monoglycerides, diglycerides, fatty acids and liquid fatty oils; and lecithin in an amount equal to 10% to 80% by weight of the total lecithin fraction.
Claim 8
Dependent Claim
63 words
An anhydrous lecithin fraction capable of being sterilized and stored for long periods of time prior to combining with water for human injection, said lecithin fraction comprising an anhydrous liquid selected from the group consisting essentially of ethanol, monoglycerides, diglycerides, fatty acids and liquid fatty oils; and lecithin in an amount equal to 10% to 80% by weight of the total lecithin fraction.
Claim 9
Dependent Claim
15 words
The lecithin fraction of claim 5 further comprising oil soluble medicaments including oil soluble vitamins.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-24 | 1984-08-25 | 1985-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-24 | 1988-08-25 | 1989-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-24 | 1992-08-25 | 1993-02-24 | $7700.00 | Window Closed / Lapsed |