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Patent US4252790A successfully refreshed from Google Patents.
US4252790A
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US
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Method for treating gastric ulcer-prone patients
Assignee: Interx Research Corp
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Filing: 1974-10-23
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Granted: 1981-02-24
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Expires: 1994-10-23
Abstract
Abstract Gastric ulcer-prone patients are treated by introducing into the stomach thereof an effective amount of a non-toxic, non-absorbable active agent, preferably an anion exchange resin having strong hydrophobic binding tendencies (e.g., a styrene-divinylbenzene copolymer bearing quaternary ammonium functional groups), or a hydrophobic, nonionic polymeric adsorbent, capable of effectively binding free and conjugated bile acids present in the stomach as a result of duodenogastric regurgitation.
Inventors
- 👤 Takeru Higuchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K33/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
118 words
A method for treating gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, which method comprises periodically co-administering into the stomach of such patient (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, styrene-divinylbenzene copolymer anion exchange resin bearing quaternary ammonium functional groups, together with (2) a bile acid buffering amount of a pharmaceutically acceptable alkalizer; and whereby there is thus counteracted the elevated level of such gastric bile acids in the stomach caused by said pyloric incompetence.
Claim 2
Independent Claim
118 words
A method for treating gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, which method comprises periodically co-administering into the stomach of such patient (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, styrene-divinylbenzene copolymer anion exchange resin bearing quaternary ammonium functional groups, together with (2) a bile acid buffering amount of a pharmaceutically acceptable alkalizer; and whereby there is thus counteracted the elevated level of such gastric bile acids in the stomach caused by said pyloric incompetence.
Claim 3
Independent Claim
115 words
A method for treating gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, which method comprises periodically co-administering into the stomach of such patient (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, cholestyramine anion exchange resin, together with (2) a bile acid buffering amount of a pharmaceutically acceptable aluminum hydroxide gel alkalizer; and whereby there is thus counteracted the elevated level of such gastric bile acids in the stomach caused by said pyloric incompetence.
Claim 4
Independent Claim
115 words
A method for treating gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, which method comprises periodically co-administering into the stomach of such patient (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, cholestyramine anion exchange resin, together with (2) a bile acid buffering amount of a pharmaceutically acceptable aluminum hydroxide gel alkalizer; and whereby there is thus counteracted the elevated level of such gastric bile acids in the stomach caused by said pyloric incompetence.
Claim 5
Dependent Claim
22 words
The method of claim 1, wherein from 25 to 500 mgs. of said active agent are co-administered into the stomach per dose.
Claim 6
Dependent Claim
15 words
The method of claim 1, wherein said active agent is orally co-administered into the stomach.
Claim 7
Dependent Claim
13 words
The method of claim 4, wherein said active agent is in tablet form.
Claim 8
Dependent Claim
22 words
The method of claim 1, wherein from 2,000 to 8,000 mgs. of said active agent are co-administered into the stomach per day.
Claim 9
Dependent Claim
14 words
The method of claim 4, wherein said active agent is formulated in liquid form.
Claim 10
Dependent Claim
40 words
The method of claim 1, wherein said pharmaceutically acceptable alkalizer is a member selected from the group consisting of sodium bicarbonate, milk of magnesia, calcium carbonate, an aluminum hydroxide gel, a sulphated magnesium hydroxy aluminate, a silicate, and mixtures thereof.
Claim 11
Dependent Claim
30 words
The method of claim 1, wherein the effective amount of active agent is co-administered into the stomach during a period when the ulcerogenic effect of refluxing bile acids is enhanced.
Claim 12
Dependent Claim
11 words
The method of claim 1, wherein said patient is gastric ulcer-prone.
Claim 13
Dependent Claim
110 words
A pharmaceutical composition for the treatment of gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, and suited for regulating the regurgitation of duodenal contents into the stomach, said composition essentially consisting of a unit dosage formulation of (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, styrene-divinyl-benzene copolymer anion exchange resin bearing quaternary ammonium functional groups, together with (2) a bile acid buffering amount of a pharmaceutically acceptable alkalizer.
Claim 14
Dependent Claim
110 words
A pharmaceutical composition for the treatment of gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, and suited for regulating the regurgitation of duodenal contents into the stomach, said composition essentially consisting of a unit dosage formulation of (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, styrene-divinyl-benzene copolymer anion exchange resin bearing quaternary ammonium functional groups, together with (2) a bile acid buffering amount of a pharmaceutically acceptable alkalizer.
Claim 15
Dependent Claim
114 words
A pharmaceutical composition for the treatment of gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, and suited for regulating the regurgitation of duodenal contents into the stomach, said composition essentially consisting of a unit dosage formulation of (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, cholestyramine anion exchange resin, together with (2) a bile acid buffering amount of a pharmaceutically acceptable aluminum hydroxide gel alkalizer, and (3) a pharmaceutically effective inert carrier.
Claim 16
Dependent Claim
114 words
A pharmaceutical composition for the treatment of gastric ulcers in a patient afflicted with pyloric incompetence and concomitant duodenogastric regurgitation of bile acids, and suited for regulating the regurgitation of duodenal contents into the stomach, said composition essentially consisting of a unit dosage formulation of (1) an effective, bile acid conjugating amount of a non-toxic, non-absorbable resinous active agent capable of effectively binding the free and conjugated bile acids present in the stomach as a result of said duodenogastric regurgitation, said resinous active agent being a hydrophobic, cholestyramine anion exchange resin, together with (2) a bile acid buffering amount of a pharmaceutically acceptable aluminum hydroxide gel alkalizer, and (3) a pharmaceutically effective inert carrier.
Claim 17
Dependent Claim
40 words
The composition of claim 11, wherein said pharmaceutically acceptable alkalizer is a member selected from the group consisting of sodium bicarbonate, milk of magnesia, calcium carbonate, an aluminum hydroxide gel, a sulphated magnesium hydroxy aluminate, a silicate, and mixtures thereof.
Claim 18
Dependent Claim
19 words
The composition of claim 13, wherein the effective amount of said active agent ranges from 25 to 500 mgs.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-24 | 1984-08-25 | 1985-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-24 | 1988-08-25 | 1989-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-24 | 1992-08-25 | 1993-02-24 | $7700.00 | Window Closed / Lapsed |