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US4250318A
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Novel 5-hydroxymethyl oxazolidinones, the method of preparing them and their application in therapeutics
Assignee: Synthelabo SA
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Filing: 1978-08-09
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Granted: 1981-02-10
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Expires: 1998-08-09
Abstract
Abstract There are disclosed 3-substituted phenyl-5-hydroxymethyl oxazolidinones which possess anti-depressant properties. The compounds are prepared by cyclizing, with ethyl carbonate, 1-substituted phenylamino-2,3-propanediol compounds.
Inventors
- 👤 Philippe L. Dostert
- 👤 Colette A. Douzon
- 👤 Guy R. Bourgery
- 👤 Claude G. Gouret
- 👤 Gisele C. Mocquet
- 👤 Jean-Alain Coston
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:47
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/02; C07D263/08; C07D263/16; C07D263/18; C07D263/20; C07D263/24; A; A61; A61P; A61P25/00; A61P25/24; A61P25/26
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
105 words
A compound having the formula ##STR97## in which R is selected from the group consisting of: a group having the formula ##STR98## situated in para position and in which R 3 is selected from the group consisting of 2-cyano, 3-chloro, 3-bromo, 3-nitro, 3-cyano, 4-acetamido and 4--NHCOC 2 H 5 ; and a group having the formula ##STR99## situated in para position and in which the combination of (R 4 , R 5 ) is selected from the group consisting of (3--Cl, 4--Cl), (3--Cl, 5--Cl), (3--Cl, 4--F), (3--NO 2 , 4--Cl), (3--CN, 4--F), (3--NO 2 , 4--F), (3--NO 2 , 5--CN) and (3--NO 2 , 5--Cl).
Claim 2
Dependent Claim
105 words
A compound having the formula ##STR97## in which R is selected from the group consisting of: a group having the formula ##STR98## situated in para position and in which R 3 is selected from the group consisting of 2-cyano, 3-chloro, 3-bromo, 3-nitro, 3-cyano, 4-acetamido and 4--NHCOC 2 H 5 ; and a group having the formula ##STR99## situated in para position and in which the combination of (R 4 , R 5 ) is selected from the group consisting of (3--Cl, 4--Cl), (3--Cl, 5--Cl), (3--Cl, 4--F), (3--NO 2 , 4--Cl), (3--CN, 4--F), (3--NO 2 , 4--F), (3--NO 2 , 5--CN) and (3--NO 2 , 5--Cl).
Claim 3
Dependent Claim
12 words
A compound as claimed in claim 1 in which R is ##STR100##
Claim 4
Dependent Claim
12 words
A compound as claimed in claim 2 in which R is ##STR101##
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 2 in which R is ##STR102##
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1 in which R is ##STR103##
Claim 7
Dependent Claim
12 words
A compound as claimed in claim 5 in which R is ##STR104##
Claim 8
Dependent Claim
12 words
A compound as claimed in claim 5 in which R is ##STR105##
Claim 9
Dependent Claim
12 words
A compound as claimed in claim 5 in which R is ##STR106##
References Cited (Backward Citations)
US3654298A
Cited
US3655687A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-10 | 1984-08-11 | 1985-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-10 | 1988-08-11 | 1989-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-10 | 1992-08-11 | 1993-02-10 | $7700.00 | Window Closed / Lapsed |