US4250139A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microwave sterilization of dry protein
Assignee: Angiotech Biomaterials Corp
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Filing: 1979-02-01
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Granted: 1981-02-10
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Expires: 1999-02-01
Abstract
Abstract Method for decontaminating proteinaceous host materials from microorganisms, while retaining chemical, physical and physiological properties of said host proteinaceous materials, said method comprising substantially dehydrating said host proteinaceous material, preferably by lyophilization, and subjecting said host material to a lethal dosage of microwave energy while said host material is maintained in substantially ambient conditions.
Inventors
- 👤 Edward E. Luck
- 👤 John R. Daniels
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:41
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61L2/08; A61L2/12; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
68 words
A method for disinfecting a host protein having physiological properties for use in a mammalian host without significantly affecting the physiological, chemical and physical properties of said host protein, said method comprising applying to said host protein substantially freed of water a lethal dosage of microave energy at a temperature above ambient temperature and below about 75° C. and for a time sufficient to decontaminate said host protein.
Claim 2
Independent Claim
68 words
A method for disinfecting a host protein having physiological properties for use in a mammalian host without significantly affecting the physiological, chemical and physical properties of said host protein, said method comprising applying to said host protein substantially freed of water a lethal dosage of microave energy at a temperature above ambient temperature and below about 75° C. and for a time sufficient to decontaminate said host protein.
Claim 3
Dependent Claim
14 words
A method according to claim 1, wherein said host protein is dried by lyophilization.
Claim 4
Dependent Claim
20 words
A method according to claim 2, wherein said time is in the range of about 1 min to 6 hrs.
Claim 5
Dependent Claim
22 words
A method according to claim 3, wherein said microwave energy is in the range of about 850 to 3,000 megacycles per second.
Claim 6
Independent Claim
16 words
A method according to any of claims 1 to 4, wherein said host protein is collagen.
Claim 7
Independent Claim
20 words
A method according to any of claims 1 to 4, wherein said host protein is at least one serum protein.
Claim 8
Independent Claim
89 words
A method for sterilizing a host proteinaceous material for use in a mammlian host obtained as an aqueous dispersion without significantly affecting the physiological, chemical and physical properties of said host protein, said method comprising: lyophilizing said aqueous dispersion at a temperature below about 50° C. to provide a lyophilized protein product; and irradiating said lyophilized protein product with a lethal dosage of microwave radiation for a time sufficient to sterilize said protein, while maintaining the temperature of said host protein above about ambient and below about 60° C.
Claim 9
Independent Claim
89 words
A method for sterilizing a host proteinaceous material for use in a mammlian host obtained as an aqueous dispersion without significantly affecting the physiological, chemical and physical properties of said host protein, said method comprising: lyophilizing said aqueous dispersion at a temperature below about 50° C. to provide a lyophilized protein product; and irradiating said lyophilized protein product with a lethal dosage of microwave radiation for a time sufficient to sterilize said protein, while maintaining the temperature of said host protein above about ambient and below about 60° C.
Claim 10
Dependent Claim
11 words
A method according to claim 7, wherein said protein is collagen.
Claim 11
Dependent Claim
15 words
A method according to claim 7, wherein said protein is at least one serum protein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-10 | 1984-08-11 | 1985-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-10 | 1988-08-11 | 1989-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-10 | 1992-08-11 | 1993-02-10 | $7700.00 | Window Closed / Lapsed |