Patent US4248892A successfully refreshed from Google Patents.
US4248892A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antifibrotic agent
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1979-06-07
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Granted: 1981-02-03
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Expires: 1999-06-07
Abstract
Abstract Compounds of the formula ##STR1## wherein n is equal to zero or 1 and their physiologically acceptable salts are effective for the prophylaxis or treatment of the fibrosis due to excessive collagen accumulation in mammal.
Inventors
- 👤 Tsuneo Kanamaru
- 👤 Takenori Ishimaru
- 👤 Hisayoshi Okazaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:57
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61P; A61P1/00; A61P1/16; A61P11/00; A61P3/00; A61P37/00; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
44 words
A method for the prophylaxis or treatment of fibrosis due to excessive collagen accumulation in mammal, which comprises administering to mammal an effective amount of a compound of the formula ##STR4## wherein n is equal to zero or 1, or its physiologically acceptable salt.
Claim 2
Independent Claim
44 words
A method for the prophylaxis or treatment of fibrosis due to excessive collagen accumulation in mammal, which comprises administering to mammal an effective amount of a compound of the formula ##STR4## wherein n is equal to zero or 1, or its physiologically acceptable salt.
Claim 3
Dependent Claim
18 words
A method according to claim 1, wherein n is equal to zero, namely the compound is protocatechuic acid.
Claim 4
Dependent Claim
21 words
A method according to claim 1, wherein the fibrosis is pulmonary fibrosis, hepatic cirrhosis, renal sclerosis, arteriosclerosis, scleroderma or rheumatoid arthritis.
Claim 5
Dependent Claim
12 words
A method according to claim 3, wherein the fibrosis is pulmonary fibrosis.
Claim 6
Dependent Claim
12 words
A method according to claim 3, wherein the fibrosis is hepatic cirrhosis.
Claim 7
Dependent Claim
17 words
A method according to claim 1, wherein the compound or its physiologically acceptable salt is orally administered.
Claim 8
Dependent Claim
30 words
A method according to claim 6, wherein the compound or its physiologically acceptable salt is administered at the dose level of 5 mg/kg to 100 mg/kg body weight per day.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-03 | 1984-08-04 | 1985-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-03 | 1988-08-04 | 1989-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-03 | 1992-08-04 | 1993-02-03 | $7700.00 | Window Closed / Lapsed |