US4248878A
Expired / Lapsed
US
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Imidazole derivatives of 1,5,6,11-tetrahydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridines
Assignee: ER Squibb and Sons LLC
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Filing: 1979-10-17
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Granted: 1981-02-03
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Expires: 1999-10-17
Abstract
Abstract New imidazole derivatives of 1,5,6,11-tetrahydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]-pyridines have the general formula ##STR1## wherein R 1 and R 2 may be the same or different and each may be hydrogen, lower alkyl, phenyl-lower alkyl, phenyl or substituted phenyl, and R 3 and R 4 may be the same or different and each may be hydrogen, halogen, lower alkyl, or lower alkoxy. They and the salts thereof are useful as antimicrobial agents, and in particular as antifungal agents.
Inventors
- 👤 Hans Hoehn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 12:58
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P31/00; A61P31/04; A61P33/00; A61P33/02
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
77 words
A compound of the formula ##STR8## wherein R 1 and R 2 may be the same or different and each is hydrogen, lower alkyl, phenyl-lower alkyl, phenyl or substituted phenyl wherein the phenyl group bears one halogen, hydroxy, lower alkoxy, lower alkyl, lower alkylthio, cyano or nitro group, and R 3 and R 4 may be the same or different and each is hydrogen, halogen, lower alkyl or lower alkoxy, and non-toxic physiologically acceptable acid-addition salts thereof.
Claim 2
Dependent Claim
77 words
A compound of the formula ##STR8## wherein R 1 and R 2 may be the same or different and each is hydrogen, lower alkyl, phenyl-lower alkyl, phenyl or substituted phenyl wherein the phenyl group bears one halogen, hydroxy, lower alkoxy, lower alkyl, lower alkylthio, cyano or nitro group, and R 3 and R 4 may be the same or different and each is hydrogen, halogen, lower alkyl or lower alkoxy, and non-toxic physiologically acceptable acid-addition salts thereof.
Claim 3
Dependent Claim
13 words
The compound as defined in claim 1 wherein R 1 is lower alkyl.
Claim 4
Dependent Claim
19 words
The compound as defined in claim 1 wherein R 2 , R 3 and R 4 are each hydrogen.
Claim 5
Dependent Claim
25 words
The compound as defined in claim 1 wherein R 1 is lower alkyl, and R 2 , R 3 and R 4 are each hydrogen.
Claim 6
Dependent Claim
14 words
The compound as defined in claim 1 in the form of its hydrochloride salt.
Claim 7
Dependent Claim
15 words
The compound as defined in claim 4 having the name 1-ethyl-1,5,6,11-tetrahydro-11-(1H-imidazol-1-yl)benzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3e]-pyridine or its hydrochloride salt.
Claim 8
Dependent Claim
24 words
An antimicrobial composition consisting essentially of an antimicrobially effective amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 9
Dependent Claim
28 words
A method for treating bacterial or fungal infections in mammals which comprises administering to a mammalian host an effective amount of a composition as defined in claim 7.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-03 | 1984-08-04 | 1985-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-03 | 1988-08-04 | 1989-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-03 | 1992-08-04 | 1993-02-03 | $7700.00 | Window Closed / Lapsed |