Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use

Claim 1

A nitro-substituted 1,4-dihydropyridine of the general formula ##STR26## in which R represents hydrogen, a straight-chain or branched alkyl radical having 1 to 8 carbon atoms, which is optionally interrupted in the alkyl chain by one or two oxygen atoms to form oxa- or dioxa-substituents, or represents a phenyl or benzyl radical R 1 and R 4 independently denote hydrogen, a straight-chain or branched alkyl radical with 1 to 4 carbon atoms, or a phenyl or benzyl radical, R 2 represents hydrogen or a nitro group, or denotes a group COR 5 , in which R 5 represents a C 1 -C 4 -alkyl, phenyl or benzyl radical or a group OR 6 , in which R 6 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical with up to 8 carbon atoms, which is optionally interrupted in the chain by 1 or 2 oxygen or sulphur atoms to form oxa-, thia, dioxa- or dithia-substituents or in which one hydrogen atom is replaced by a hydroxyl group or by a phenoxy or phenyl group which is optionally substituted by halogen, cyano, amino, alkylamino or dialkylamino with 1 to 2 carbon atoms per alkyl group, alkoxy with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms, trifluoromethyl or nitro, or by an amino group, this amino group optionally carrying either hydrogen and one substituent or two identical or different substituents selected from alkyl with 1 to 4 carbon atoms, alkoxyalkyl with up to 4 carbon atoms, phenyl and benzyl, or R 6 represents a phenyl group which is optionally substituted by 1 or 2 identical or different substituents selected from alkyl with 1 to 4 carbon atoms, phenyl, benzyl, alkoxy with 1 to 4 carbon atoms, halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, amino and alkylamino with 1 to 4 carbon atoms, and R 3 represents a phenyl or naphthyl radical optionally containing 1 or 2 identical or different substituents selected from phenyl, alkyl with 1 to 8 carbon atoms, alkenyl or alkinyl each with 2 to 6 carbon atoms, alkoxy with 1 to 4 carbon atoms, alkenoxy or alkinoxy with 2 to 6 carbon atoms, dioxymethylene, halogen, trifluoromethyl, trifluoromethoxy, hydroxyl, amino, alkylamino with 1 to 4 carbon atoms, nitro, cyano, azido, carboxyl, carbalkoxy with 2 to 4 carbon atoms, carboxamido, sulphonamido, SO m alkyl with 1 to 4 carbon atoms, and SO m -trifluoroalkyl