Patent US4212428A successfully refreshed from Google Patents.
Patent US4246347A successfully refreshed from Google Patents.
US4246347A
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Process for the production of fructose
Assignee: Novartis Vaccines and Diagnostics Inc
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Filing: 1979-10-24
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Granted: 1981-01-20
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Expires: 1999-10-24
Abstract
Abstract A process is described for the production of fructose from glucose. An aqueous solution of glucose is converted to D-glucosone by an enzymatic process. D-glucosone is then converted to substantially pure fructose by chemical hydrogenation. Fructose may be recovered in crystalline form.
Inventors
- 👤 Saul L. Neidleman
- 👤 William F. Amon, Jr.
- 👤 John Geigert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:35
CPC Classifications
C; C07; C07C; C07C29/00; C07C29/09; C07C29/10; C07D; C07D301/00; C07D301/02; C12; C12N; C12N9/00; C12N9/0004; C12N9/0065; C12N9/0071; C12P; C12P17/00; C12P17/02; C12P7/00; C12P7/02; C12P7/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
45 words
A method for making fructose from glucose, comprising, providing an aqueous solution of D-glucose, converting at least about ninty-five percent of the D-glucose in solution to D-glucosone in solution by enzymatic oxidation while removing or utilizing co-produced hydrogen perioxide, and hydrogenating the D-glucosone to D-fructose.
Claim 2
Independent Claim
45 words
A method for making fructose from glucose, comprising, providing an aqueous solution of D-glucose, converting at least about ninty-five percent of the D-glucose in solution to D-glucosone in solution by enzymatic oxidation while removing or utilizing co-produced hydrogen perioxide, and hydrogenating the D-glucosone to D-fructose.
Claim 3
Dependent Claim
14 words
A method according to claim 1 wherein the D-fructose is recovered in crystalline form.
Claim 4
Dependent Claim
13 words
A method according to claim 2 wherein the D-fructose is recovered by evaporation.
Claim 5
Dependent Claim
13 words
A method according to claim 2 wherein the D-fructose is recovered by precipitation.
Claim 6
Dependent Claim
36 words
A method according to claim 2 wherein the D-glucosone in solution is recovered as a syrup and is resolubolized in an organic solvent, and wherein the hydrogenation of the D-glucosone causes direct precipitation of fructose crystals.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein the enzyme comprises an oxidoreductase having glucose-2-oxidase activity.
Claim 8
Dependent Claim
26 words
A method according to claim 6 wherein the enzyme is selected from the group consisting of glucose-2-oxidase from Aspergillus oryzae and carbohydrate oxidase from Polyporus obtusus.
Claim 9
Dependent Claim
11 words
A method according to claim 6 wherein the enzyme is immobilized.
Claim 10
Dependent Claim
17 words
A method according to claim 1 wherein the hydrogen peroxide is removed by enzymatic decomposition by catalase.
Claim 11
Dependent Claim
15 words
A method according to claim 1 wherein the hydrogen peroxide is utilized in a co-process.
Claim 12
Dependent Claim
42 words
A method according to claim 1 wherein the hydrogenation step is catalyzed by a hydrogenation catalyst selected from the group consisting of the Group VIII elements, the metallic elements of Groups IB and IIB and the transition elements chromium, tungsten and manganese.
Claim 13
Dependent Claim
15 words
A method according to claim 11 wherein the hydrogenating catalyst comprises palladium on a support.
Claim 14
Independent Claim
58 words
A method for making crystalline fructose from glucose, comprising, providing an aqueous solution of D-glucose, converting at least about ninty-five percent of the D-glucose in solution to D-glucosone in solution by utilizing an immobilized oxidoreductase enzyme having glucose-2-oxidase activity while removing or utilizing co-produced hydrogen peroxide, hydrogenating the D-glucosone to D-fructose, and recovering the D-fructose in crystalline form.
Claim 15
Independent Claim
58 words
A method for making crystalline fructose from glucose, comprising, providing an aqueous solution of D-glucose, converting at least about ninty-five percent of the D-glucose in solution to D-glucosone in solution by utilizing an immobilized oxidoreductase enzyme having glucose-2-oxidase activity while removing or utilizing co-produced hydrogen peroxide, hydrogenating the D-glucosone to D-fructose, and recovering the D-fructose in crystalline form.
Claim 16
Dependent Claim
14 words
A method according to claim 12 which is carried out in a column reactor.
References Cited (Backward Citations)
US3050444A
Cited
US3868304A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-20 | 1984-07-21 | 1985-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-20 | 1988-07-21 | 1989-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-20 | 1992-07-21 | 1993-01-20 | $7700.00 | Window Closed / Lapsed |