Derivatives of amidinopenicillanic acid

Claim 1

A 6β-amidinopenicillanic acid of the general formula I: ##STR29## in which X stands for an oxygen or a sulphur atom, --A-- stands for a straight or branched, aliphatic hydrocarbon chain, containing from 2 to 4 carbon atoms, or --A-- can be a single bond, and --B-- stands for a straight or branched, saturated or unsaturated aliphatic hydrocarbon radical, containing from 1 to 4 carbon atoms, or --B-- can be a single bond; R 1 and R 2 stand for hydrogen, or a lower alkyl radical containing from 1 to 4 carbon atoms, a phenyl or phenyl-lower alkyl radical; and R 2 further stands for an acyl radical derived from a mono- or dibasic carboxylic acid, sulphuric acid, a sulphonic acid, a sulphinic acid, phosphoric acid, or a phosphoric acid, or R 2 can represent an unsubstituted or a lower alkyl or phenyl substituted radical selected from the group consisting of carbamoyl, guanyl and guanylcarbamoyl radicals; or R 1 and R 2 together with the nitrogen atom can form a monocyclic saturated ring having from 4 to 8 carbon atoms; and furthermore R 1 and R 2 together can represent a radical of the formula ##STR30## in which R 3 and R 4 each stands for hydrogen, lower alkyl, phenyl, or phenyl-lower alkyl radicals, or in which R 3 and R 4 together with the nitrogen atom form a monocyclic, saturated ring having from 4 to 8 carbon atoms; and in which the radical --W-- stands for the groupings: ##STR31## which represent saturated, monocyclic, bicyclic or spirocyclic ring systems, respectively, containing from 4 to 11 carbon atoms in total; and salts of the compounds of the formula I with pharmaceutically acceptable, non-toxic organic and inorganic and inorganic acids or bases, and easily hydrolyzable, pharmaceutically acceptable, non-toxic esters of the penicillanic acid derivatives of formula I and salts of such esters with pharmaceutically acceptable, non-toxic acids or bases.