US4242505A
Expired / Lapsed
US
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S-Adenosyl-L-methionine compositions and production thereof
Assignee: Yamasa Shoyu KK
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Filing: 1978-07-28
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Granted: 1980-12-30
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Expires: 1998-07-28
Abstract
Abstract S-adenosyl-L-methionine compositions stabilized against decomposition of S-adenosyl-L-methionine comprising S-adenosyl-L-methionine, a sulfuric acid equivalent and a nucleoside sulfate, which are produced from a solution comprising the three essential components in an aqueous solvent by, for example, adding thereto a water-miscible organic solvent thereby to precipitate the composition (process A) and/or by evaporating the aqueous solvent off the solution (process B).
Inventors
- 👤 Toshihisa Kawahara
- 👤 Goro Motoki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:47
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; G; G11; G11B; G11B27/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
18 words
An S-adenosyl-L-methionine composition stabilized against decomposition of S-adenosyl-L-methionine comprising S-adenosyl-L-methionine, a sulfuric acid equivalent, and a nucleoside sulfate.
Claim 2
Dependent Claim
18 words
An S-adenosyl-L-methionine composition stabilized against decomposition of S-adenosyl-L-methionine comprising S-adenosyl-L-methionine, a sulfuric acid equivalent, and a nucleoside sulfate.
Claim 3
Dependent Claim
42 words
The composition as set forth in claim 1, in which the molar ratio of the components is 1 part of S-adenosyl-L-methionine to from 1 to 3 parts of the sulfuric acid equivalent to not less than 0.5 part of the nucleoside sulfate.
Claim 4
Dependent Claim
31 words
The composition as set forth in claim 1, in which the nucleoside sulfate is a member selected from the group consisting of a nucleoside monosulfate, a nucleoside disulfate, and mixtures thereof.
Claim 5
Dependent Claim
43 words
The composition as set forth in claim 3, in which the nucleoside monosulfate is a member selected from the group consisting of inosine-5'-monosulfate, adenosine-5'-monosulfate, guanosine-5'-monosulfate, uridine-5'-monosulfate, cytidine-5'-monosulfate, xanthosine-5'-monosulfate,thymidine-5'-monosulfate, deoxyguanosine-5'-monosulfate, deoxyinosine-5'-monosulfate, inosine-2'(3')-monosulfate, adenosine-2'(3')-monosulfate, guanosine-2'(3')-monosulfate, cytidine-2'(3')-monosulfate, uridine-2')3')-monosulfate, thymidine-3'-monosulfate, deoxyinosine-3'-monosulfate, deoxyadenosine-3'-monosulfate, deoxyguanosine-3'-monosulfate, deoxycytidine-3'-monosulfate, and mixtures thereof.
Claim 6
Dependent Claim
43 words
The composition as set forth in claim 3, in which the nucloside disulfate is a member selected from the group consisting of inosine-2'(3'),5'-disulfate, adenosine-2'(3'),5'-disulfate, guanosine-2'(3'),5'-disulfate, xanthosine-2'(3'),5'-disulfate, uridine-2'(3'),5'-disulfate, cytidine-2'(3'),5'-disulfate, thymidine-3',5'-disulfate, deoxyinosine-3',5'-disulfate, deoxyadenosine-3',5'-disulfate, deoxyguanosine-3',5'-disulfate deoxyxanthosine-3',5'-disulfate, deoxycytidine-3',5'-disulfate, adenosine-2',3'-disulfate, inosine-2',3'-disulfate, guanosine-2',3'-disulfate, xanthosine-2',3'-disulfate, cytidine-2',3'-disulfate, uridine-2',3'-disulfate, and mixtures thereof.
Claim 7
Dependent Claim
31 words
The composition as set forth in claim 2, in which the nucleoside sulfate is a member selected from the group consisting of a nucleoside monosulfate, a nucleoside disulfate, and mixtures thereof.
Claim 8
Dependent Claim
44 words
The composition as set forth in claim 6, in which the nucleoside monosulfate is a member selected from the group consisting of inosine-5'-monosulfate, adenosine-5'-monosulfate, guanosine-5'-monosulfate, uridine-5'-monosulfate, cytidine-5'-monosulfate, xanthosine-5'-monosulfate, thymidine-5'-monosulfate, deoxyguanosine-5'-monosulfate, deoxyinosine-5'-monosulfate, inosine-2'(3')-monosulfate, adenosine-2'(3')-monosulfate, guanosine-2'(3')-monosulfate, cytidine-2'(3')-monosulfate, uridine-2'(3')-monosulfate, thymidine-3'-monosulfate, deoxyinosine-3'-monosulfate, deoxyadenosine-3'-monosulfate, deoxyguanosine-3'-monosulfate, deoxycytidine-3'-monosulfate, and mixtures thereof.
Claim 9
Dependent Claim
43 words
The composition as set forth in claim 6, in which the nucloside disulfate is a member selected from the group consisting of inosine-2'(3'),5'-disulfate, adenosine-2'(3'),5'-disulfate, guanosine-2'(3'),5'-disulfate, xanthosine-2'(3'),5'-disulfate, uridine-2'(3'),5'-disulfate, cytidine-2'(3'),5'-disulfate, thymidine-3',5'-disulfate, deoxyinosine-3',5'-disulfate, deoxyadenosine-3',5'-disulfate, deoxyguanosine-3',5'-disulfate, deoxyxanthosine-3',5'-disulfate, deoxycytidine-3',5'-disulfate, adenosine-2',3'-disulfate, inosine-2',3'-disulfate, guanosine-2',3'-disulfate, xanthosine-2',3'-disulfate, cytidine-2',3'-disulfate, uridine-2',3'-disulfate, and mixtures thereof.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1983-12-30 | 1984-06-30 | 1984-12-30 | $2000.00 | Window Closed / Lapsed |
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