US4109079A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilized s-adenosyl-l-methionine preparations
Assignee: Yamasa Shoyu KK
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Filing: 1976-10-14
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Granted: 1978-08-22
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Expires: 1996-10-14
Abstract
Abstract A stabilized dry S-adenosyl-L-methionine preparation is obtained by incorporating about 1 - 10 parts by weight of lithium in the form of a salt with 100 parts by weight of S-adenosyl-L-methionine or a low-toxicity salt thereof. According to the invention, instability of S-adenosyl-L-methionine or a salt thereof is substantially eliminated. The stabilized dry preparation is very useful as medical drugs and reagents for biochemical research.
Inventors
- 👤 Toshihisa Kawahara
- 👤 Goro Motoki
- 👤 Kazuo Uchida
- 👤 Hiroshi Yoshino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:28
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; A; A61; A61K; A61K47/00; A61K47/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
49 words
A stabilized dry S-adenosyl-L-methionine preparation which comprises S-adenosyl-L-methionine or a pharmaceutically acceptable salt thereof and an effective amount of a lithium salt which is pharmaceutically acceptable and is soluble in an acidic solution of the S-adenosyl-L-methionine or a pharmaceutically acceptable salt thereof and does not make the solution alkaline.
Claim 2
Dependent Claim
49 words
A stabilized dry S-adenosyl-L-methionine preparation which comprises S-adenosyl-L-methionine or a pharmaceutically acceptable salt thereof and an effective amount of a lithium salt which is pharmaceutically acceptable and is soluble in an acidic solution of the S-adenosyl-L-methionine or a pharmaceutically acceptable salt thereof and does not make the solution alkaline.
Claim 3
Dependent Claim
21 words
The preparation as set forth in claim 1, in which the preparation contains not more than 3% by weight of moisture.
Claim 4
Dependent Claim
29 words
The preparation as set forth in claim 1, in which the S-adenosyl-L-methionine salt is selected from the group consisting of the hydrochloride, sulfate, iodide, bromide and Reinecke's salt thereof.
Claim 5
Dependent Claim
47 words
The preparation as set forth in claim 1, in which the lithium salt is selected from the group consisting of lithium chloride, lithium bromide, lithium iodide, lithium sulfate, lithium nitrate, lithium phosphate, lithium borate, lithium carbonate, lithium formate, lithium acetate, lighium citrate, lithium succinate and lithium benzoate.
Claim 6
Dependent Claim
70 words
The preparation as set forth in claim 1, in which the preparation comprises S-adenosyl-L-methionine or a pharmaceutically acceptable salt thereof and a lithium salt which is pharmaceutically acceptable and is soluble in an acidic solution of the S-adenosyl-L-methionine or a pharmaceutically acceptable salt thereof and does not make the solution alkaline, added thereto in an amount of about 1 to 10% by weight as lithium of the amount of S-adenosyl-L-methionine.
Claim 7
Dependent Claim
21 words
The preparation as set forth in claim 5, in which the preparation contains not more than 2% by weight of moisture.
Claim 8
Dependent Claim
29 words
The preparation as set forth in claim 5, in which the S-adenosyl-L-methionine salt is selected from the group consisting of the hydrochloride, sulfate, iodide, bromide and Reinecke's salt thereof.
Claim 9
Dependent Claim
45 words
The preparation as set forth in claim 5, in which the lithium salt is selected from the group consisting of lithium chloride, lithium bromide, lithium iodide, lithium sulfate, lithium nitrate, lithium borate, lithium carbonate, lithium formate, lithium acetate, lithium citrate, lithium succinate and lithium benzoate.
Claim 10
Dependent Claim
16 words
The preparation as set forth in claim 5, in which the S-adenosyl-L-methionine salt is hydrochloride thereof.
Claim 11
Dependent Claim
17 words
The preparation as set forth in claim 9, in which the lithium salt is a halide thereof.
Claim 12
Dependent Claim
25 words
The preparation according to claim 1 wherein the lithium salt is selected from the group consisting of chloride, bromide, sulfate, carbonate, acetate, citrate and succinate.
Claim 13
Dependent Claim
25 words
The preparation according to claim 5 wherein the lithium salt is selected from the group consisting of chloride, bromide, sulfate, carbonate, acetate, citrate and succinate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-21 | 1982-02-20 | 1982-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-21 | 1986-02-20 | 1986-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-21 | 1990-02-20 | 1990-08-22 | $7700.00 | Window Closed / Lapsed |