US3707536A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the isolation and purification of s-adenosyl methionine and ethionine and novel sulfates thereof
Assignee: Roche Diagnostics GmbH
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Filing: 1970-04-13
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Granted: 1972-12-26
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Expires: 1990-04-13
Abstract
Abstract S-ADENOSYL-1-METHIONINE AND S-ADENOSYL-1-ETHIONINE ARE OBTAINED FROM YEAST IN SUBSTANTIALLY PURE FORM AND IN HIGH YIELD BY SUBJECTING THE YEAST TO ACID DIGESTION AND CATION EXCHANGE CHROMATOGRAPHY AND TO EITHER ONE OR BOTH OF THE PROCESS STEPS OF (1) PICRIC ACID PRECIPITATION AND (2) BORIC ACID ADDITION TO GIVE A BORATE COMPLEX WHICH IS THEN CHROMATOGRAPHED THROUGH AN ANION EXCHANGER AT A WEAKLY ALKALINE PH, WHICH PROCESS STEPS (1) AND (2), IF BOTH ARE UTILIZED, CAN BE CARRIED OUT IN EITHER SEQUENC. NEW S-ADENOSYL-1-METHIONINE BISUFATE AND S-ADENOSYL-1-ETHIONINE OF EXCEPTIONAL STABILITY ARE ALSO PROVIDED.
Inventors
- 👤 Erich Haid
- 👤 Michael Nelboeck-Hochstetter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:09
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C12; C12P; C12P19/00; C12P19/26; C12P19/28; C12P19/38; C12P19/40
Claims Analysis
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References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-12-26 | 1976-06-26 | 1976-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-12-26 | 1980-06-26 | 1980-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-12-26 | 1984-06-26 | 1984-12-26 | $7700.00 | Window Closed / Lapsed |