Patent US4242359A successfully refreshed from Google Patents.
US4242359A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Spermicidal agents
Assignee: Cornell Research Foundation Inc
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Filing: 1978-12-11
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Granted: 1980-12-30
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Expires: 1998-12-11
Abstract
Abstract Disclosed is a method for treating mammalian spermatozoa with amphipathic amines in order to induce loss of fertility and/or head-tail cleavage of the sperms under mild physiological conditions. In the presence of primary alkyl or cycloalkyl amines containing between 4 to 7 carbon atoms at concentrations of about 15 lambda /ml, sperms are rapidly dissociated into heads and tails under physiological pH- and temperature-conditions. Further disclosed are topical contraceptive compositions containing amphipathic amines.
Inventors
- 👤 George W. Cooper
- 👤 Ronald J. Young
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K9/00; A61K9/0012; A61K9/0034; Y; Y10; Y10S; Y10S424/00; Y10S424/14
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
45 words
A method for killing mammalian spermatozoa, which comprises contacting spermatozoa with a spermicidally effective amount of an amphipathic organic amine of the formula (I) ##STR3## wherein R 1 represents hydrogen, and R 2 represents an alkyl-, cycloalkyl- or cycloalkylalkyl-group containing 3 to 7 carbon atoms.
Claim 2
Independent Claim
45 words
A method for killing mammalian spermatozoa, which comprises contacting spermatozoa with a spermicidally effective amount of an amphipathic organic amine of the formula (I) ##STR3## wherein R 1 represents hydrogen, and R 2 represents an alkyl-, cycloalkyl- or cycloalkylalkyl-group containing 3 to 7 carbon atoms.
Claim 3
Dependent Claim
15 words
The method as defined in claim 1, wherein R 2 represents a primary alkyl group.
Claim 4
Dependent Claim
12 words
The method as defined in claim 1, wherein R 2 represents n-butyl.
Claim 5
Dependent Claim
12 words
The method as defined in claim 1, wherein R 2 represents isobutyl.
Claim 6
Dependent Claim
12 words
The method as defined in claim 1, wherein R 2 represents cyclohexyl.
Claim 7
Dependent Claim
81 words
A method for preventing pregnancy which comprises the step of applying to the vaginal cavity of a mammalian female an amount of a topical contraceptive composition having a semi-solid or solid consistency, exhibiting a pH-value of between about 4.5 and about 7.5 and comprising a non-toxic conception-inhibiting amount of an aphipathic amine as defined in claim 1 per single dosage unit and a physiologically acceptable carrier, said amount being sufficient to prevent the entry of fertilizing sperms into the female cervix.
Claim 8
Dependent Claim
25 words
The method as defined in claim 6, wherein the amount of the topical contraceptive composition comprises about 5 to about 500 mg of the amine.
Claim 9
Dependent Claim
25 words
The method as defined in claim 7, wherein the amount of the topical contraceptive formulation comprises about 5 to about 300 mg of the amine.
Claim 10
Dependent Claim
12 words
A method as defined by claim 6, wherein R 2 represents n-butyl.
Claim 11
Dependent Claim
12 words
A method as defined by claim 6, wherein R 2 represents isobutyl.
Claim 12
Dependent Claim
12 words
A method as defined by claim 6, wherein R 2 represents cyclohexyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-30 | 1984-06-30 | 1984-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-30 | 1988-06-30 | 1988-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-30 | 1992-06-30 | 1992-12-30 | $7700.00 | Window Closed / Lapsed |