N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines

Claim 1

A compound of the formula ##STR37## or a pharmacologically acceptable salt thereof, wherein A is of the formula: ##STR38## wherein R 1 and R 2 can be the same or different and each represents hydrogen, halogen, hydroxy, trifluoromethyl, alkoxy containing 1 to 7 carbon atoms and either unsubstituted or substituted by aryl or cycloalkyl, or amino either unsubstituted or substituted with at least one acyl or alkyl, each containing 1 to 7 carbon atoms, the alkyl being unsubstituted or substituted by aryl or cycloalkyl; or R 1 and R 2 are interconnected forming a group having terminal oxygen atoms which are separated by methylene or ethylene and which are attached to adjacent carbon atoms on the phenyl ring; X represents --O--, --S--, or --N--; R 3 represents hydrogen, halogen or alkyl containing 1 to 7 carbon atoms: R 4 represents hydrogen or alkyl containing 1 to 7 carbon atoms when X is --S-- or ##STR39## and represents hydrogen when S is O; R 5 is alkylene of 1 to 6 carbon atoms; R 6 and R 7 can be the same or different and each represents hydrogen, cycloalkyl or alkyl, each containing 1 to 7 carbon atoms, the alkyl ether unsubstituted or substituted by aryl; or R 6 and R 7 are interconnected forming with the nitrogen atom in formula 3 a 5- or 6- membered ring which can include oxygen; and d is 0, 1 or 2 and e is 2 or 3 when A is of formula 1 or 3; d is 1 or 2 and e is 2 or 3 when A is of formula 2 and X is --S-- or ##STR40## d is 1 and e is 2 when A is of formula 2 and X is --O--; and the sum of d and e is 3 or 4.